Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

SOCS3 protein

Gene

SOCS3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Submitted name:
SOCS3 proteinImported
Submitted name:
Suppressor of cytokine signaling 3, isoform CRA_aImported
Submitted name:
cDNA, FLJ94944, highly similar to Homo sapiens suppressor of cytokine signaling 3 (SOCS3), mRNAImported
Gene namesi
Name:SOCS3Imported
ORF Names:hCG_1776363Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000184557.4.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885765.

Expressioni

Gene expression databases

BgeeiENSG00000184557.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 127SH2InterPro annotationAdd BLAST82
Domaini177 – 224SOCS boxInterPro annotationAdd BLAST48

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
HOVERGENiHBG105645.
KOiK04696.
OMAiKRTYYIY.
OrthoDBiEOG091G0NEU.

Family and domain databases

CDDicd10384. SH2_SOCS3. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR028414. SOCS3.
IPR035863. SOCS3_SH2.
IPR001496. SOCS_box.
IPR036036. SOCS_box_dom_like.
PANTHERiPTHR44534. PTHR44534. 1 hit.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FI39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA
60 70 80 90 100
VTGGEANLLL SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG
110 120 130 140 150
SFSLQSDPRS TQPVPRFDCV LKLVHHYMPP PGAPSFPSPP TEPSSEVPEQ
160 170 180 190 200
PSAQPLPGSP PRRAYYIYSG GEKIPLVLSR PLSSNVATLQ HLCRKTVNGH
210 220
LDSYEKVTQL PGPIREFLDQ YDAPL
Length:225
Mass (Da):24,770
Last modified:May 10, 2005 - v1
Checksum:i08581DC411EFFF19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei225Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314212 mRNA. Translation: BAG36886.1.
CR536497 mRNA. Translation: CAG38736.1.
CR541694 mRNA. Translation: CAG46495.1.
CH471099 Genomic DNA. Translation: EAW89521.1.
CH471099 Genomic DNA. Translation: EAW89522.1.
RefSeqiNP_003946.3. NM_003955.4.
UniGeneiHs.527973.
Hs.703620.

Genome annotation databases

GeneIDi9021.
KEGGihsa:9021.
UCSCiuc002jvl.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ6FI39_HUMAN
AccessioniPrimary (citable) accession number: Q6FI39
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 25, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.