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Protein
Submitted name:

SOCS3 protein

Gene

SOCS3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Submitted name:
SOCS3 proteinImported
Submitted name:
Suppressor of cytokine signaling 3, isoform CRA_aImported
Submitted name:
cDNA, FLJ94944, highly similar to Homo sapiens suppressor of cytokine signaling 3 (SOCS3), mRNAImported
Gene namesi
Name:SOCS3Imported
ORF Names:hCG_1776363Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885765.

Expressioni

Gene expression databases

BgeeiENSG00000184557.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330341.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 127SH2InterPro annotationAdd BLAST82
Domaini177 – 224SOCS boxInterPro annotationAdd BLAST48

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
HOVERGENiHBG105645.
KOiK04696.
OMAiKRTYYIY.
OrthoDBiEOG091G0NEU.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiIPR000980. SH2.
IPR028414. SOCS3.
IPR001496. SOCS_box.
[Graphical view]
PANTHERiPTHR24369:SF78. PTHR24369:SF78. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FI39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA
60 70 80 90 100
VTGGEANLLL SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG
110 120 130 140 150
SFSLQSDPRS TQPVPRFDCV LKLVHHYMPP PGAPSFPSPP TEPSSEVPEQ
160 170 180 190 200
PSAQPLPGSP PRRAYYIYSG GEKIPLVLSR PLSSNVATLQ HLCRKTVNGH
210 220
LDSYEKVTQL PGPIREFLDQ YDAPL
Length:225
Mass (Da):24,770
Last modified:May 10, 2005 - v1
Checksum:i08581DC411EFFF19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei225Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314212 mRNA. Translation: BAG36886.1.
CR536497 mRNA. Translation: CAG38736.1.
CR541694 mRNA. Translation: CAG46495.1.
CH471099 Genomic DNA. Translation: EAW89521.1.
CH471099 Genomic DNA. Translation: EAW89522.1.
RefSeqiNP_003946.3. NM_003955.4.
UniGeneiHs.527973.
Hs.703620.

Genome annotation databases

GeneIDi9021.
KEGGihsa:9021.
UCSCiuc002jvl.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314212 mRNA. Translation: BAG36886.1.
CR536497 mRNA. Translation: CAG38736.1.
CR541694 mRNA. Translation: CAG46495.1.
CH471099 Genomic DNA. Translation: EAW89521.1.
CH471099 Genomic DNA. Translation: EAW89522.1.
RefSeqiNP_003946.3. NM_003955.4.
UniGeneiHs.527973.
Hs.703620.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000330341.

Protocols and materials databases

DNASUi9021.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9021.
KEGGihsa:9021.
UCSCiuc002jvl.4. human.

Organism-specific databases

CTDi9021.
PharmGKBiPA134885765.

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
HOVERGENiHBG105645.
KOiK04696.
OMAiKRTYYIY.
OrthoDBiEOG091G0NEU.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiSOCS3. human.
GenomeRNAii9021.

Gene expression databases

BgeeiENSG00000184557.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiIPR000980. SH2.
IPR028414. SOCS3.
IPR001496. SOCS_box.
[Graphical view]
PANTHERiPTHR24369:SF78. PTHR24369:SF78. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FI39_HUMAN
AccessioniPrimary (citable) accession number: Q6FI39
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.