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Protein
Submitted name:

GSK3B protein

Gene

GSK3B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
GSK3B proteinImported
Submitted name:
GSK3beta isoformImported
Submitted name:
Glycogen synthase kinase 3 beta, isoform CRA_bImported
Submitted name:
cDNA FLJ75266, highly similar to Homo sapiens glycogen synthase kinase 3 beta, mRNAImported
Gene namesi
Name:GSK3BImported
ORF Names:hCG_1818062Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000082701.14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29009.

PTM / Processingi

Proteomic databases

MaxQBiQ6FI27.

Expressioni

Gene expression databases

BgeeiENSG00000082701.
ExpressionAtlasiQ6FI27. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiQ6FI27. 1 interactor.
MINTiMINT-8085587.

Structurei

3D structure databases

SMRiQ6FI27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 340Protein kinaseInterPro annotationAdd BLAST285

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0658. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG014652.
KOiK03083.

Family and domain databases

InterProiView protein in InterPro
IPR033573. GSK3B.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PANTHERiPTHR24057:SF26. PTHR24057:SF26. 1 hit.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FI27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR
60 70 80 90 100
PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI
110 120 130 140 150
MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK
160 170 180 190 200
QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD
210 220 230 240 250
FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL
260 270 280 290 300
LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP
310 320 330 340 350
WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL
360 370 380 390 400
PNGRDTPALF NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA
410 420
NTGDRGQTNN AASASASNST
Length:420
Mass (Da):46,744
Last modified:May 10, 2005 - v1
Checksum:i4ACC24D00CDBB9C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU302497 mRNA. Translation: ABX89591.1.
AK290897 mRNA. Translation: BAF83586.1.
CR536510 mRNA. Translation: CAG38748.1.
CH471052 Genomic DNA. Translation: EAW79534.1.
CH471052 Genomic DNA. Translation: EAW79535.1.
RefSeqiNP_001139628.1. NM_001146156.1.
UniGeneiHs.445733.

Genome annotation databases

GeneIDi2932.
KEGGihsa:2932.
UCSCiuc003edo.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ6FI27_HUMAN
AccessioniPrimary (citable) accession number: Q6FI27
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 27, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.