Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

MAP2K3 protein

Gene

MAP2K3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
MAP2K3 proteinImported
Submitted name:
Mitogen-activated protein kinase kinase 3 isoform BImported
Submitted name:
cDNA, FLJ96569, Homo sapiens mitogen-activated protein kinase kinase 3 (MAP2K3),transcript variant B, mRNAImported
Gene namesi
Name:MAP2K3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30588.

PTM / Processingi

Proteomic databases

MaxQBiQ6FI23.

Expressioni

Gene expression databases

BgeeiENSG00000034152.
ExpressionAtlasiQ6FI23. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345083.

Structurei

3D structure databases

SMRiQ6FI23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 325Protein kinaseInterPro annotationAdd BLAST262

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0984. Eukaryota.
ENOG410XT3F. LUCA.
HOVERGENiHBG108518.
KOiK04432.
OMAiPFFTSHK.
OrthoDBiEOG091G0A9H.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FI23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI
60 70 80 90 100
TIGDRNFEVE ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN
110 120 130 140 150
SQEQKRLLMD LDINMRTVDC FYTVTFYGAL FREGDVWICM ELMDTSLDKF
160 170 180 190 200
YRKVLDKNMT IPEDILGEIA VSIVRALEHL HSKLSVIHRD VKPSNVLINK
210 220 230 240 250
EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL NQKGYNVKSD
260 270 280 290 300
VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD
310 320 330 340
FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS
Length:347
Mass (Da):39,318
Last modified:May 10, 2005 - v1
Checksum:iA80BA4FDFF8F75A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei347Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315505 mRNA. Translation: BAG37889.1.
AB451226 mRNA. Translation: BAG70040.1.
AB451349 mRNA. Translation: BAG70163.1.
CR536514 mRNA. Translation: CAG38752.1.
RefSeqiNP_659731.1. NM_145109.2.
UniGeneiHs.514012.

Genome annotation databases

GeneIDi5606.
KEGGihsa:5606.
UCSCiuc002gys.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315505 mRNA. Translation: BAG37889.1.
AB451226 mRNA. Translation: BAG70040.1.
AB451349 mRNA. Translation: BAG70163.1.
CR536514 mRNA. Translation: CAG38752.1.
RefSeqiNP_659731.1. NM_145109.2.
UniGeneiHs.514012.

3D structure databases

SMRiQ6FI23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000345083.

Proteomic databases

MaxQBiQ6FI23.

Protocols and materials databases

DNASUi5606.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5606.
KEGGihsa:5606.
UCSCiuc002gys.4. human.

Organism-specific databases

CTDi5606.
PharmGKBiPA30588.

Phylogenomic databases

eggNOGiKOG0984. Eukaryota.
ENOG410XT3F. LUCA.
HOVERGENiHBG108518.
KOiK04432.
OMAiPFFTSHK.
OrthoDBiEOG091G0A9H.

Miscellaneous databases

ChiTaRSiMAP2K3. human.
GenomeRNAii5606.

Gene expression databases

BgeeiENSG00000034152.
ExpressionAtlasiQ6FI23. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FI23_HUMAN
AccessioniPrimary (citable) accession number: Q6FI23
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: March 15, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.