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Protein
Submitted name:

CYR61 protein

Gene

CYR61

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25UDPCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandNucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
CYR61 proteinImported
Submitted name:
Cysteine-rich, angiogenic inducer, 61, isoform CRA_aImported
Gene namesi
Name:CYR61Imported
ORF Names:hCG_23652Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27126.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501050674325 – 381Sequence analysisAdd BLAST357

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ6FI18.

Expressioni

Gene expression databases

BgeeiENSG00000142871.
ExpressionAtlasiQ6FI18. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D0ZX-ray2.20X/Y24-29[»]
4D11X-ray2.85L/O/P/X/Z24-29[»]
SMRiQ6FI18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 94IGFBP N-terminalInterPro annotationAdd BLAST73
Domaini98 – 164VWFCInterPro annotationAdd BLAST67
Domaini286 – 360CTCK (C-terminal cystine knot-like)InterPro annotationAdd BLAST75

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IIY0. Eukaryota.
ENOG41119KZ. LUCA.
HOVERGENiHBG000635.
KOiK06829.
OMAiKCIVQTT.
OrthoDBiEOG091G0SQP.

Family and domain databases

InterProiView protein in InterPro
IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. TSP1_rpt.
IPR001007. VWF_dom.
PfamiView protein in Pfam
PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00093. VWC. 1 hit.
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiView protein in SMART
SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiView protein in PROSITE
PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FI18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC
60 70 80 90 100
GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC
110 120 130 140 150
EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL
160 170 180 190 200
VKVTGQCCEE WVCDEDSIKD PMEDQDGLLG KELGFDASEV ELTRNNELIA
210 220 230 240 250
VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS KTCGTGISTR
260 270 280 290 300
VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY
310 320 330 340 350
AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI
360 370 380
QSCKCNYNCP HANEAAFPFY RLFNDIHKFR D
Length:381
Mass (Da):42,027
Last modified:May 10, 2005 - v1
Checksum:iFC0BD39C078CA0B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314571 mRNA. Translation: BAG37152.1.
CR536519 mRNA. Translation: CAG38757.1.
CH471097 Genomic DNA. Translation: EAW73196.1.
CH471097 Genomic DNA. Translation: EAW73198.1.
RefSeqiNP_001545.2. NM_001554.4.
UniGeneiHs.8867.

Genome annotation databases

GeneIDi3491.
KEGGihsa:3491.
UCSCiuc001dle.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ6FI18_HUMAN
AccessioniPrimary (citable) accession number: Q6FI18
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: August 30, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

3D-structureCombined sources