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Protein
Submitted name:

CYR61 protein

Gene

CYR61

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 251UDPCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
CYR61 proteinImported
Submitted name:
Cysteine-rich, angiogenic inducer, 61, isoform CRA_aImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:CYR61Imported
ORF Names:hCG_23652Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27126.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 381357Sequence analysisPRO_5007708165Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ6FI18.

Expressioni

Gene expression databases

BgeeiENSG00000142871.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000398736.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4D0ZX-ray2.20X/Y24-29[»]
4D11X-ray2.85L/O/P/X/Z24-29[»]
SMRiQ6FI18. Positions 296-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 9473IGFBP N-terminalInterPro annotationAdd
BLAST
Domaini98 – 16467VWFCInterPro annotationAdd
BLAST
Domaini286 – 36075CTCK (C-terminal cystine knot-like)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains CTCK (C-terminal cystine knot-like) domain.SAAS annotation
Contains IGFBP N-terminal domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IIY0. Eukaryota.
ENOG41119KZ. LUCA.
HOVERGENiHBG000635.
KOiK06829.
OMAiKCIVQTT.
OrthoDBiEOG091G0SQP.
PhylomeDBiQ6FI18.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. TSP1_rpt.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FI18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC
60 70 80 90 100
GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC
110 120 130 140 150
EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL
160 170 180 190 200
VKVTGQCCEE WVCDEDSIKD PMEDQDGLLG KELGFDASEV ELTRNNELIA
210 220 230 240 250
VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS KTCGTGISTR
260 270 280 290 300
VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY
310 320 330 340 350
AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI
360 370 380
QSCKCNYNCP HANEAAFPFY RLFNDIHKFR D
Length:381
Mass (Da):42,027
Last modified:May 10, 2005 - v1
Checksum:iFC0BD39C078CA0B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314571 mRNA. Translation: BAG37152.1.
CR536519 mRNA. Translation: CAG38757.1.
CH471097 Genomic DNA. Translation: EAW73196.1.
CH471097 Genomic DNA. Translation: EAW73198.1.
RefSeqiNP_001545.2. NM_001554.4.
UniGeneiHs.8867.

Genome annotation databases

GeneIDi3491.
KEGGihsa:3491.
UCSCiuc001dle.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314571 mRNA. Translation: BAG37152.1.
CR536519 mRNA. Translation: CAG38757.1.
CH471097 Genomic DNA. Translation: EAW73196.1.
CH471097 Genomic DNA. Translation: EAW73198.1.
RefSeqiNP_001545.2. NM_001554.4.
UniGeneiHs.8867.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4D0ZX-ray2.20X/Y24-29[»]
4D11X-ray2.85L/O/P/X/Z24-29[»]
SMRiQ6FI18. Positions 296-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000398736.

Proteomic databases

MaxQBiQ6FI18.

Protocols and materials databases

DNASUi3491.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3491.
KEGGihsa:3491.
UCSCiuc001dle.4. human.

Organism-specific databases

CTDi3491.
PharmGKBiPA27126.

Phylogenomic databases

eggNOGiENOG410IIY0. Eukaryota.
ENOG41119KZ. LUCA.
HOVERGENiHBG000635.
KOiK06829.
OMAiKCIVQTT.
OrthoDBiEOG091G0SQP.
PhylomeDBiQ6FI18.

Miscellaneous databases

ChiTaRSiCYR61. human.
GenomeRNAii3491.

Gene expression databases

BgeeiENSG00000142871.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. TSP1_rpt.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FI18_HUMAN
AccessioniPrimary (citable) accession number: Q6FI18
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.