Q6FI14 (Q6FI14_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
GRAP2 protein EMBL CAG38761.1

Submitted name:
GRB2-related adaptor protein 2, isoform CRA_a EMBL EAW60356.1
Submitted name:
cDNA, FLJ93267, Homo sapiens GRB2-related adaptor protein 2 (GRAP2), mRNA EMBL BAG35685.1

Gene names

Name:	GRAP2 EMBL CAG38761.1
ORF Names:	hCG_41723 EMBL EAW60356.1

Organism

Homo sapiens (Human) EMBL CAG38761.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 2 SH3 domains. RuleBase RU003338

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338 SAAS SAAS000980
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6FI14 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 74F4C8D0EBB56D55	FASTA	330	37,909
	10 20 30 40 50 60 MEAVAKFDFT ASGEDELSFH TGDVLKILSN QEEWFKAELG SQEGYVPKNF IDIQFPKWFH 70 80 90 100 110 120 EGLSRHQAEN LLMGKEVGFF IIRASQSSPG DFSISVRHED DVQHFKVMRD NKGNYFLWTE 130 140 150 160 170 180 KFPSLNKLVD YYRTNSISRQ KQIFLRDRTR EDQGHRGNSL DRRSQGGPHL SGAVGEEIRP 190 200 210 220 230 240 SMNRKLSDHP PTLPLQQHQH QPQPPQYAPA PQQLQQPPQQ RYLQHHHFHQ ERRGGSLDIN 250 260 270 280 290 300 DGHCGTGLGS EMNAALMHRR HTDPVQLQAA GRVRWARALY DFEALEDDEL GFHSGEVVEV 310 320 330 LDSSNPSWWT GRLHNKLGLF PANYVAPMTR

References

[1]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Thymus EMBL BAG35685.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK312830 mRNA. Translation: BAG35685.1. CR536524 mRNA. Translation: CAG38761.1. CH471095 Genomic DNA. Translation: EAW60356.1.
IPI	IPI00026928.
RefSeq	NP_004801.1. NM_004810.2.
UniGene	Hs.517499.
3D structure databases
ProteinModelPortal	Q6FI14.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FI14.
Proteomic databases
PRIDE	Q6FI14.
Protocols and materials databases
DNASU	9402.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9402.
KEGG	hsa:9402.
Organism-specific databases
CTD	9402.
PharmGKB	PA28959.
Phylogenomic databases
HOVERGEN	HBG005404.
KO	K07366.
OMA	HTGDILK.
PhylomeDB	Q6FI14.
Gene expression databases
ArrayExpress	Q6FI14.
Bgee	Q6FI14.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR000980. SH2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00017. SH2. 1 hit. PF00018. SH3_1. 2 hits. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN.
SMART	SM00252. SH2. 1 hit. SM00326. SH3. 2 hits. [Graphical view]
SUPFAM	SSF50044. SH3. 2 hits.
PROSITE	PS50001. SH2. 1 hit. PS50002. SH3. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GRAP2. human.
GenomeRNAi	9402.
NextBio	35223.

Entry information

Entry name

Q6FI14_HUMAN

Accession

Primary (citable) accession number: Q6FI14

Entry history

Integrated into UniProtKB/TrEMBL:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.