Q6FI05 (Q6FI05_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
CDKN1A protein EMBL CAG38770.1

Submitted name:
Cyclin-dependent kinase inhibitor 1A EMBL BAG70104.1
Submitted name:
Cyclin-dependent kinase inhibitor 1A (P21, Cip1) EMBL AAP35365.1
Submitted name:
Cyclin-dependent kinase inhibitor 1A (P21, Cip1), isoform CRA_a EMBL EAX03904.1

Gene names

Name:	CDKN1A EMBL CAG38770.1
ORF Names:	hCG_15367 EMBL EAX03904.1

Organism

Homo sapiens (Human) EMBL CAG38770.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Cyclin EMBL AAP35365.1 Kinase EMBL AAP35365.1 Transferase
Gene Ontology (GO)
Biological_process	epidermal growth factor receptor signaling pathway Traceable author statement. Source: Reactome fibroblast growth factor receptor signaling pathway Traceable author statement. Source: Reactome mitotic cell cycle arrest Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: Compara negative regulation of gene expression Inferred from electronic annotation. Source: Compara nerve growth factor receptor signaling pathway Traceable author statement. Source: Reactome organ regeneration Inferred from electronic annotation. Source: Compara phosphatidylinositol-mediated signaling Traceable author statement. Source: Reactome positive regulation of B cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of programmed cell death Inferred from electronic annotation. Source: Compara regulation of DNA biosynthetic process Inferred from electronic annotation. Source: Compara regulation of mitotic cell cycle Inferred from electronic annotation. Source: Compara regulation of protein import into nucleus, translocation Inferred from electronic annotation. Source: Compara response to DNA damage stimulus Inferred from electronic annotation. Source: Compara response to UV Inferred from electronic annotation. Source: Compara response to arsenic-containing substance Inferred from electronic annotation. Source: Compara response to corticosterone stimulus Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to gamma radiation Inferred from expression pattern PubMed 7958916. Source: BHF-UCL response to hyperoxia Inferred from electronic annotation. Source: Compara response to organic nitrogen Inferred from electronic annotation. Source: Compara response to toxin Inferred from electronic annotation. Source: Compara
Cellular_component	cyclin-dependent protein kinase holoenzyme complex Inferred from electronic annotation. Source: Compara cytosol Traceable author statement. Source: Reactome nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	cyclin-dependent protein serine/threonine kinase inhibitor activity Traceable author statement PubMed 7958916. Source: BHF-UCL kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	164	1	EMBL BAG70236.1

Sequences

	Sequence		Length	Mass (Da)
	Q6FI05 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 98D1E7C519ADFCA9	FASTA	164	18,119
	10 20 30 40 50 60 MSEPAGDVRQ NPCGSKACRR LFGPVDSEQL SRDCDALMAG CIQEARERWN FDFVTETPLE 70 80 90 100 110 120 GDFAWERVRG LGLPKLYLPT GPRRGRDELG GGRRPGTSPA LLQGTAEEDH VDLSLSCTLV 130 140 150 160 PRSGEQAEGS PGGPGDSQGR KRRQTSMTDF YHSKRRLIFS KRKP

References

[1]	"Cloning of human full-length CDSs in BD Creator(TM) System Donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Human Protein Factory: an infrastructure to convert the human transcriptome into the in vitro-expressed human proteome of versatile utility." Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J.-I., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B. , Kenmochi K.-I., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J.-I., Watanabe S., Nomura N. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT006719 mRNA. Translation: AAP35365.1. AB451290 mRNA. Translation: BAG70104.1. AB451422 mRNA. Translation: BAG70236.1. CR536533 mRNA. Translation: CAG38770.1. CH471081 Genomic DNA. Translation: EAX03904.1.
IPI	IPI00009384.
RefSeq	NP_000380.1. NM_000389.4. NP_001207706.1. NM_001220777.1. NP_001207707.1. NM_001220778.1. NP_510867.1. NM_078467.2.
UniGene	Hs.370771. Hs.732576.
3D structure databases
ProteinModelPortal	Q6FI05.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FI05.
Proteomic databases
PRIDE	Q6FI05.
Protocols and materials databases
DNASU	1026.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1026.
KEGG	hsa:1026.
Organism-specific databases
CTD	1026.
PharmGKB	PA104.
Phylogenomic databases
HOVERGEN	HBG050868.
KO	K06625.
PhylomeDB	Q6FI05.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_116125. Disease. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q6FI05.
Bgee	Q6FI05.
Family and domain databases
InterPro	IPR003175. CDI. [Graphical view]
PANTHER	PTHR10265. PTHR10265. 1 hit.
Pfam	PF02234. CDI. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CDKN1A. human.
GenomeRNAi	1026.
NextBio	4309.

Entry information

Entry name

Q6FI05_HUMAN

Accession

Primary (citable) accession number: Q6FI05

Entry history

Integrated into UniProtKB/TrEMBL:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.