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Protein
Submitted name:

TCF2 protein

Gene

TCF2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi231 – 311HomeoboxPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
TCF2 proteinImported
Submitted name:
Transcription factor 2, hepatic LF-B3 variant hepatic nuclear factor, isoform CRA_bImported
Submitted name:
Transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factorImported
Submitted name:
cDNA FLJ76233, highly similar to Homo sapiens transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor (TCF2), transcript variant a, mRNAImported
Gene namesi
Name:TCF2Imported
ORF Names:hCG_27684Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000275410.4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391083

PTM / Processingi

Proteomic databases

MaxQBiQ6FHW6

Expressioni

Gene expression databases

BgeeiENSG00000275410
ExpressionAtlasiQ6FHW6 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ6FHW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini229 – 310HomeoboxInterPro annotationAdd BLAST82

Keywords - Domaini

HomeoboxPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFA0 Eukaryota
ENOG410ZZZ0 LUCA
HOVERGENiHBG005980
KOiK08034
OMAiQQPFMAT
OrthoDBiEOG091G052F

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR006899 HNF-1_N
IPR023219 HNF1_dimer_N_dom_sf
IPR006897 HNF1b_C
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF04814 HNF-1_N, 1 hit
PF04812 HNF-1B_C, 1 hit
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF100957 SSF100957, 1 hit
SSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6FHW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSKLTSLQQ ELLSALLSSG VTKEVLVQAL EELLPSPNFG VKLETLPLSP
60 70 80 90 100
GSGAEPDTKP VFHTLTNGHA KGRLSGDEGS EDGDDYDTPP ILKELQALNT
110 120 130 140 150
EEAAEQRAEV DRMLSEDPWR AAKMIKGYMQ QHNIPQREVV DVTGLNQSHL
160 170 180 190 200
SQHLNKGTPM KTQKRAALYT WYVRKQREIL RQFNQTVQSS GNMTDKSSQD
210 220 230 240 250
QLLFLFPEFS QQSHGPGQSD DACSEPTNKK MRRNRFKWGP ASQQILYQAY
260 270 280 290 300
DRQKNPSKEE REALVEECNR AECLQRGVSP SKAHGLGSNL VTEVRVYNWF
310 320 330 340 350
ANRRKEEAFR QKLAMDAYSS NQTHSLNPLL SHGSPHHQPS SSPPNKLSGV
360 370 380 390 400
RYSQQGNNEI TSSSTISHHG NSAMVTSQSV LQQVSPASLD PGHNLLSPDG
410 420 430 440 450
KMISVSGGGL PPVSTLTNIH SLSHHNPQQS QNLIMTPLSG VMAIAQSLNT
460 470 480 490 500
SQAQSVPVIN SVAGSLAALQ PVQFSQQLHS PHQQPLMQQS PGSHMAQQPF
510 520 530 540 550
MAAVTQLQNS HMYAHKQEPP QYSHTSRFPS AMVVTDTSSI STLTNMSSSK

QCPLQAW
Length:557
Mass (Da):61,324
Last modified:May 10, 2005 - v1
Checksum:i9E1ECC7423B73980
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007126 mRNA Translation: AAP35790.1
AK290131 mRNA Translation: BAF82820.1
CR536572 mRNA Translation: CAG38809.1
CH471199 Genomic DNA Translation: EAW57603.1
RefSeqiNP_000449.1, NM_000458.3
UniGeneiHs.191144

Genome annotation databases

GeneIDi6928
KEGGihsa:6928
UCSCiuc002hok.5 human

Similar proteinsi

Entry informationi

Entry nameiQ6FHW6_HUMAN
AccessioniPrimary (citable) accession number: Q6FHW6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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