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Protein
Submitted name:

TCF7L2 protein

Gene

TCF7L2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi327 – 395HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
TCF7L2 proteinImported
Submitted name:
Transcription factor 7-like 2 (T-cell specific, HMG-box), isoform CRA_eImported
Gene namesi
Name:TCF7L2Imported
ORF Names:hCG_40998Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36394.

Expressioni

Gene expression databases

BgeeiENSG00000148737.
ExpressionAtlasiQ6FHW4. baseline and differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6FHW4. 1 interactor.

Structurei

3D structure databases

SMRiQ6FHW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini327 – 395HMG box DNA-bindingInterPro annotationAdd BLAST69

Phylogenomic databases

HOVERGENiHBG000419.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
4.10.900.10. 1 hit.
InterProiView protein in InterPro
IPR027397. Catenin_binding_dom.
IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR024940. TCF/LEF.
IPR028773. TCF7L2.
PANTHERiPTHR10373. PTHR10373. 1 hit.
PTHR10373:SF44. PTHR10373:SF44. 1 hit.
PfamiView protein in Pfam
PF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FHW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN
60 70 80 90 100
ESETNQNSSS DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY
110 120 130 140 150
PGYPFIMIPD LTSPYLPNGS LSPTARTYLQ MKWPLLDVQA GSLQSRQALK
160 170 180 190 200
DARSPSPAHI VSNKVPVVQH PHHVHPLTPL ITYSNEHFTP GNPPPHLPAD
210 220 230 240 250
VDPKTGIPRP PHPPDISPYY PLSPGTVGQI PHPLGWLVPQ QGQPVYPITT
260 270 280 290 300
GGFRHPYPTA LTVNASMSRF PPHMVPPHHT LHTTGIPHPA IVTPTVKQES
310 320 330 340 350
SQSDVGSLHS SKHQDSKKEE EKKKPHIKKP LNAFMLYMKE MRAKVVAECT
360 370 380 390 400
LKESAAINQI LGRRWHALSR EEQAKYYELA RKERQLHMQL YPGWSARDNY
410 420 430 440 450
GKKKKRKRDK QPGETNEHSE CFLNPCLSLP PITDLSAPKK CRARFGLDQQ
460 470 480 490 500
NNWCGPCRRK KKCVRYIQGE GSCLSPPSSD GSLLDSPPPS PNLLGSPPRD
510 520 530 540 550
AKSQTEQTQP LSLSLKPDPL AHLSMMPPPP ALLLAEATHK ASALCPNGAL
560 570 580 590
DLPPAALQPA APSSSIAQPS TSSLHSHSSL AGTQPQPLSL VTKSLE
Length:596
Mass (Da):65,291
Last modified:May 10, 2005 - v1
Checksum:iA022284FEC164B09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR536574 mRNA. Translation: CAG38811.1.
CH471066 Genomic DNA. Translation: EAW49510.1.
RefSeqiNP_110383.2. NM_030756.4.
UniGeneiHs.593995.

Genome annotation databases

GeneIDi6934.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ6FHW4_HUMAN
AccessioniPrimary (citable) accession number: Q6FHW4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: July 5, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.