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Protein
Submitted name:

ENO2 protein

Gene

ENO2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei158SubstrateUniRule annotation1
Binding sitei167SubstrateUniRule annotation1
Active sitei210Proton donorUniRule annotation1
Binding sitei293SubstrateUniRule annotation1
Binding sitei318SubstrateUniRule annotation1
Active sitei343Proton acceptorUniRule annotation1
Binding sitei394SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ENO2 proteinImported
Submitted name:
Enolase 2 (Gamma, neuronal), isoform CRA_aImported
Submitted name:
Epididymis secretory protein Li 279Imported
Submitted name:
cDNA FLJ42665 fis, clone BRAMY2019989, highly similar to Gamma-enolase (EC 4.2.1.11)Imported
Submitted name:
cDNA, FLJ92734, Homo sapiens enolase 2, (gamma, neuronal) (ENO2), mRNAImported
Gene namesi
Name:ENO2Imported
Synonyms:HEL-S-279Imported
ORF Names:hCG_25937Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27788.

Expressioni

Gene expression databases

BgeeiENSG00000111674.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EXOC5Q8IW243EBI-10249724,EBI-10171392

Protein-protein interaction databases

STRINGi9606.ENSP00000229277.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 134Enolase_NInterPro annotationAdd BLAST132
Domaini142 – 431Enolase_CInterPro annotationAdd BLAST290

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni370 – 373Substrate bindingUniRule annotation4

Phylogenomic databases

eggNOGiKOG2670. Eukaryota.
COG0148. LUCA.
HOVERGENiHBG000067.
KOiK01689.
OMAiDQTLICG.
OrthoDBiEOG091G07NH.

Family and domain databases

CDDicd03313. enolase. 1 hit.
Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_00318. Enolase. 1 hit.
InterProiIPR000941. Enolase.
IPR020810. Enolase_C.
IPR029065. Enolase_C-like.
IPR020809. Enolase_CS.
IPR020811. Enolase_N.
IPR029017. Enolase_N-like.
[Graphical view]
PANTHERiPTHR11902. PTHR11902. 1 hit.
PfamiPF00113. Enolase_C. 1 hit.
PF03952. Enolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001400. Enolase. 1 hit.
PRINTSiPR00148. ENOLASE.
SMARTiSM01192. Enolase_C. 1 hit.
SM01193. Enolase_N. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR01060. eno. 1 hit.
PROSITEiPS00164. ENOLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FHV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIEKIWARE ILDSRGNPTV EVDLYTAKGL FRAAVPSGAS TGIYEALELR
60 70 80 90 100
DGDKQRYLGK GVLKAVDHIN STIAPALISS GLSVVEQEKL DNLMLELDGT
110 120 130 140 150
ENKSKFGANA ILGVSLAVCK AGAAERELPL YRHIAQLAGN SDLILPVPAF
160 170 180 190 200
NVINGGSHAG NKLAMQEFMI LPVGAESFRD AMRLGAEVYH TLKGVIKDKY
210 220 230 240 250
GKDATNVGDE GGFAPNILEN SEALELVKEA IDKAGYTEKI VIGMDVAASE
260 270 280 290 300
FYRDGKYDLD FKSPTDPSRY ITGDQLGALY QDFVRDYPVV SIEDPFDQDD
310 320 330 340 350
WAAWSKFTAN VGIQIVGDDL TVTNPKRIER AVEEKACNCL LLKVNQIGSV
360 370 380 390 400
TEAIQACKLA QENGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR
410 420 430
SERLAKYNQL MRIEEELGDE ARFAGHNFRN PSVL
Length:434
Mass (Da):47,269
Last modified:May 10, 2005 - v1
Checksum:i6163DE81F5C67744
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU794607 mRNA. Translation: ACJ13661.1.
AK312402 mRNA. Translation: BAG35316.1.
AK124656 mRNA. Translation: BAG54062.1.
CR536582 mRNA. Translation: CAG38819.1.
CH471116 Genomic DNA. Translation: EAW88709.1.
CH471116 Genomic DNA. Translation: EAW88710.1.
CH471116 Genomic DNA. Translation: EAW88711.1.
RefSeqiNP_001966.1. NM_001975.2.
UniGeneiHs.511915.

Genome annotation databases

GeneIDi2026.
KEGGihsa:2026.
UCSCiuc001qru.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU794607 mRNA. Translation: ACJ13661.1.
AK312402 mRNA. Translation: BAG35316.1.
AK124656 mRNA. Translation: BAG54062.1.
CR536582 mRNA. Translation: CAG38819.1.
CH471116 Genomic DNA. Translation: EAW88709.1.
CH471116 Genomic DNA. Translation: EAW88710.1.
CH471116 Genomic DNA. Translation: EAW88711.1.
RefSeqiNP_001966.1. NM_001975.2.
UniGeneiHs.511915.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000229277.

Protocols and materials databases

DNASUi2026.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2026.
KEGGihsa:2026.
UCSCiuc001qru.1. human.

Organism-specific databases

CTDi2026.
PharmGKBiPA27788.

Phylogenomic databases

eggNOGiKOG2670. Eukaryota.
COG0148. LUCA.
HOVERGENiHBG000067.
KOiK01689.
OMAiDQTLICG.
OrthoDBiEOG091G07NH.

Miscellaneous databases

ChiTaRSiENO2. human.
GenomeRNAii2026.

Gene expression databases

BgeeiENSG00000111674.

Family and domain databases

CDDicd03313. enolase. 1 hit.
Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_00318. Enolase. 1 hit.
InterProiIPR000941. Enolase.
IPR020810. Enolase_C.
IPR029065. Enolase_C-like.
IPR020809. Enolase_CS.
IPR020811. Enolase_N.
IPR029017. Enolase_N-like.
[Graphical view]
PANTHERiPTHR11902. PTHR11902. 1 hit.
PfamiPF00113. Enolase_C. 1 hit.
PF03952. Enolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001400. Enolase. 1 hit.
PRINTSiPR00148. ENOLASE.
SMARTiSM01192. Enolase_C. 1 hit.
SM01193. Enolase_N. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR01060. eno. 1 hit.
PROSITEiPS00164. ENOLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FHV6_HUMAN
AccessioniPrimary (citable) accession number: Q6FHV6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.