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Protein

Uracil-DNA glycosylase

Gene

UNG

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei145Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processDNA damage, DNA repairUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:UNGUniRule annotationImported
Synonyms:UNG1UniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiQ6FHS8
PRIDEiQ6FHS8

Interactioni

Subunit structurei

Monomer. Interacts with FAM72A.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6FHS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 291UDGInterPro annotationAdd BLAST162

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2994 Eukaryota
COG0692 LUCA
HOGENOMiHOG000229528
HOVERGENiHBG000396

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6FHS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVFCLGPWG SGRKLRTPGK GPLQLLSRLC GDHLQAIPAK KAPAGQEEPG
60 70 80 90 100
TPPSSPLSAE QLDRIQRNKA AALLRLAARN VPVGFGESWK KHLSGEFGKP
110 120 130 140 150
YFIKLMGFVV EERKHYTVYP PPHQVFTWTQ MCDIKDVKVV ILGQDPYHGP
160 170 180 190 200
NQAHGLCFSV QRPVPPPPSL ENIYKELSTD IEDFVHPGHG DLSGWAKQGV
210 220 230 240 250
LLLNAVLTVR AHQANSHKER GWEQFTDAVV SWLNQNSNGL VFLLWGSYAQ
260 270 280 290 300
KKGSAIDRKR HHVLQTAHPS PLSVYRGFFG CRHFSKTNEL LQKSGKKPID

WKEL
Length:304
Mass (Da):33,926
Last modified:July 19, 2004 - v1
Checksum:i059A296F611A87C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR541673 mRNA Translation: CAG46474.1
UniGeneiHs.191334

Similar proteinsi

Entry informationi

Entry nameiQ6FHS8_HUMAN
AccessioniPrimary (citable) accession number: Q6FHS8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health