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Protein
Submitted name:

IRF1 protein

Gene

IRF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
IRF1 proteinImported
Submitted name:
Interferon regulatory factor 1Imported
Submitted name:
Interferon regulatory factor-1Imported
Submitted name:
cDNA, FLJ94683, Homo sapiens interferon regulatory factor 1 (IRF1), mRNAImported
Gene namesi
Name:IRF1Imported
ORF Names:hCG_24115Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29915.

PTM / Processingi

Proteomic databases

MaxQBiQ6FHN8.

Expressioni

Gene expression databases

BgeeiENSG00000125347.
ExpressionAtlasiQ6FHN8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000245414.

Structurei

3D structure databases

ProteinModelPortaliQ6FHN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 113IRF tryptophan pentad repeat DNA-bindingInterPro annotationAdd BLAST109

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IER3. Eukaryota.
ENOG4111HM7. LUCA.
HOVERGENiHBG003455.
KOiK09444.
OMAiCKEEPEV.
OrthoDBiEOG091G0CB8.
PhylomeDBiQ6FHN8.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR031215. IRF1.
IPR017431. IRF1/IRF2.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR11949. PTHR11949. 1 hit.
PTHR11949:SF37. PTHR11949:SF37. 1 hit.
PfamiView protein in Pfam
PF00605. IRF. 1 hit.
PIRSFiPIRSF038196. IFN_RF1/2. 1 hit.
PRINTSiPR00267. INTFRNREGFCT.
SMARTiView protein in SMART
SM00348. IRF. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q6FHN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKH AAKHGWDINK
60 70 80 90 100
DACLFRSWAI HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN
110 120 130 140 150
KGSSAVRVYR MLPPLTKNQR KERKSKSSRD AKSKAKRKSC GDSSPDTFSD
160 170 180 190 200
GLSSSTLPDD HSSYTVPGYM QDLEVEQALT PALSPCAVSS TLPDWHIPVE
210 220 230 240 250
VVPDSTSDLY NFQVSPMPST SEATTDEDEE GKLPEDIMKL LEQSEWQPTN
260 270 280 290 300
VDGKGYLLNE PGVQPTSVYG DFSCKEEPEI DSPGGDIGLS LQRVFTDLKN
310 320
MDATWLDSLL TPVRLPSIQA IPCAP
Length:325
Mass (Da):36,502
Last modified:May 10, 2005 - v1
Checksum:i2E06245A212D1541
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei325Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT019755 mRNA. Translation: AAV38560.1.
DQ789232 Genomic DNA. Translation: ABH05670.1.
AK314025 mRNA. Translation: BAG36735.1.
CR541713 mRNA. Translation: CAG46514.1.
CH471062 Genomic DNA. Translation: EAW62332.1.
RefSeqiNP_002189.1. NM_002198.2.
UniGeneiHs.436061.

Genome annotation databases

GeneIDi3659.
KEGGihsa:3659.
UCSCiuc003kxa.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT019755 mRNA. Translation: AAV38560.1.
DQ789232 Genomic DNA. Translation: ABH05670.1.
AK314025 mRNA. Translation: BAG36735.1.
CR541713 mRNA. Translation: CAG46514.1.
CH471062 Genomic DNA. Translation: EAW62332.1.
RefSeqiNP_002189.1. NM_002198.2.
UniGeneiHs.436061.

3D structure databases

ProteinModelPortaliQ6FHN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000245414.

Proteomic databases

MaxQBiQ6FHN8.

Protocols and materials databases

DNASUi3659.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3659.
KEGGihsa:3659.
UCSCiuc003kxa.3. human.

Organism-specific databases

CTDi3659.
PharmGKBiPA29915.

Phylogenomic databases

eggNOGiENOG410IER3. Eukaryota.
ENOG4111HM7. LUCA.
HOVERGENiHBG003455.
KOiK09444.
OMAiCKEEPEV.
OrthoDBiEOG091G0CB8.
PhylomeDBiQ6FHN8.

Miscellaneous databases

GenomeRNAii3659.

Gene expression databases

BgeeiENSG00000125347.
ExpressionAtlasiQ6FHN8. baseline and differential.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR031215. IRF1.
IPR017431. IRF1/IRF2.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR11949. PTHR11949. 1 hit.
PTHR11949:SF37. PTHR11949:SF37. 1 hit.
PfamiView protein in Pfam
PF00605. IRF. 1 hit.
PIRSFiPIRSF038196. IFN_RF1/2. 1 hit.
PRINTSiPR00267. INTFRNREGFCT.
SMARTiView protein in SMART
SM00348. IRF. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FHN8_HUMAN
AccessioniPrimary (citable) accession number: Q6FHN8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 12, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.