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Protein

Nucleoside diphosphate kinase

Gene

NME2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Gene namesi
Name:NME2Imported
Synonyms:HEL-S-155anImported
ORF Names:hCG_2001850Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000243678.11

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA250

PTM / Processingi

Proteomic databases

MaxQBiQ6FHN3
PRIDEiQ6FHN3

Expressioni

Gene expression databases

BgeeiENSG00000243678
ExpressionAtlasiQ6FHN3 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ6FHN3, 2 interactors

Structurei

3D structure databases

SMRiQ6FHN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 141NDKInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0888 Eukaryota
COG0105 LUCA
HOGENOMiHOG000224564
HOVERGENiHBG000423
KOiK00940
OrthoDBiEOG091G0PLD

Family and domain databases

Gene3Di3.30.70.141, 1 hit
HAMAPiMF_00451 NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q6FHN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVAMKF LRASEEHLKQ
60 70 80 90 100
HYIDLKDRPF FPGLVKYMNS GPVVAMVWEG LNVVKTGRVM LGETNPADSK
110 120 130 140 150
PGTIRGDFCI QVGRNIIHGS DSVKSAEKEI SLWFKPEELV DYKSCAHDWV

YE
Length:152
Mass (Da):17,298
Last modified:May 10, 2005 - v1
Checksum:i1A5C3F84D7AD272C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC095458 mRNA Translation: AAH95458.1
BT007045 mRNA Translation: AAP35694.1
EU794639 mRNA Translation: ACJ13693.1
AK313448 mRNA Translation: BAG36237.1
CR541718 mRNA Translation: CAG46519.1
CH471109 Genomic DNA Translation: EAW94564.1
CH471109 Genomic DNA Translation: EAW94567.1
RefSeqiNP_001018147.1, NM_001018137.2
NP_001018148.1, NM_001018138.1
NP_001018149.1, NM_001018139.2
NP_002503.1, NM_002512.3
UniGeneiHs.463456

Genome annotation databases

GeneIDi4831
KEGGihsa:4831
UCSCiuc002itl.3 human

Similar proteinsi

Entry informationi

Entry nameiQ6FHN3_HUMAN
AccessioniPrimary (citable) accession number: Q6FHN3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health