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Protein
Submitted name:

GNB2 protein

Gene

GNB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
GNB2 proteinImported
Submitted name:
Guanine nucleotide binding protein (G protein), beta polypeptide 2, isoform CRA_aImported
Submitted name:
cDNA FLJ77321, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNAImported
Gene namesi
Name:GNB2Imported
ORF Names:hCG_20449Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  • cell body Source: Ensembl
  • lysosomal membrane Source: UniProtKB
  • myelin sheath Source: Ensembl
  • protein complex Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28778.

Expressioni

Gene expression databases

BgeeiENSG00000172354.

Interactioni

Protein-protein interaction databases

DIPiDIP-600N.
STRINGi9606.ENSP00000305260.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 340WD_REPEATS_REGIONInterPro annotationAdd BLAST290

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 24Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, WD repeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0286. Eukaryota.
ENOG410XQUX. LUCA.
HOVERGENiHBG000188.
KOiK04537.
OMAiEPVCGIT.
OrthoDBiEOG091G0A7T.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19850. PTHR19850. 1 hit.
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FHM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELEQLRQE AEQLRNQIRD ARKACGDSTL TQITAGLDPV GRIQMRTRRT
60 70 80 90 100
LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV
110 120 130 140 150
MTCAYAPSGN FVACGGLDNI CSIYSLKTRE GNVRVSRELP GHTGYLSCCR
160 170 180 190 200
FLDDNQIITS SGDTTCALWD IETGQQTVGF AGHSGDVMSL SLAPDGRTFV
210 220 230 240 250
SGACDASIKL WDVRDSMCRQ TFIGHESDIN AVAFFPNGYA FTTGSDDATC
260 270 280 290 300
RLFDLRADQE LLMYSHDNII CGITSVAFSR SGRLLLAGYD DFNCNIWDAM
310 320 330 340
KGDRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN
Length:340
Mass (Da):37,331
Last modified:May 10, 2005 - v1
Checksum:i5D08FFA240ADEEE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291592 mRNA. Translation: BAF84281.1.
CR541729 mRNA. Translation: CAG46530.1.
CH471091 Genomic DNA. Translation: EAW76499.1.
CH471091 Genomic DNA. Translation: EAW76500.1.
CH471091 Genomic DNA. Translation: EAW76501.1.
RefSeqiNP_005264.2. NM_005273.3.
UniGeneiHs.185172.

Genome annotation databases

GeneIDi2783.
KEGGihsa:2783.
UCSCiuc003uwb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291592 mRNA. Translation: BAF84281.1.
CR541729 mRNA. Translation: CAG46530.1.
CH471091 Genomic DNA. Translation: EAW76499.1.
CH471091 Genomic DNA. Translation: EAW76500.1.
CH471091 Genomic DNA. Translation: EAW76501.1.
RefSeqiNP_005264.2. NM_005273.3.
UniGeneiHs.185172.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-600N.
STRINGi9606.ENSP00000305260.

Protocols and materials databases

DNASUi2783.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2783.
KEGGihsa:2783.
UCSCiuc003uwb.4. human.

Organism-specific databases

CTDi2783.
PharmGKBiPA28778.

Phylogenomic databases

eggNOGiKOG0286. Eukaryota.
ENOG410XQUX. LUCA.
HOVERGENiHBG000188.
KOiK04537.
OMAiEPVCGIT.
OrthoDBiEOG091G0A7T.

Miscellaneous databases

ChiTaRSiGNB2. human.
GenomeRNAii2783.

Gene expression databases

BgeeiENSG00000172354.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19850. PTHR19850. 1 hit.
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FHM2_HUMAN
AccessioniPrimary (citable) accession number: Q6FHM2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.