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Protein

Translocating chain-associated membrane protein

Gene

TRAM1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, TranslocationUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Translocating chain-associated membrane proteinUniRule annotation
Gene namesi
Name:TRAM1Imported
ORF Names:hCG_18447Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 5126HelicalSequence analysisAdd
BLAST
Transmembranei83 – 10220HelicalSequence analysisAdd
BLAST
Transmembranei123 – 14725HelicalSequence analysisAdd
BLAST
Transmembranei167 – 18519HelicalSequence analysisAdd
BLAST
Transmembranei197 – 21418HelicalSequence analysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence analysisAdd
BLAST
Transmembranei252 – 27423HelicalSequence analysisAdd
BLAST
Transmembranei294 – 31623HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134955644.

PTM / Processingi

Proteomic databases

MaxQBiQ6FHL3.

Expressioni

Gene expression databases

BgeeiENSG00000067167.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000262213.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 326210TLC (TRAM/LAG1/CLN8)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAM family.UniRule annotation
Contains TLC (TRAM/LAG1/CLN8) domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1608. Eukaryota.
ENOG410XSB3. LUCA.
HOVERGENiHBG054402.
KOiK14010.
OMAiLQLAYWF.
OrthoDBiEOG091G077N.
PhylomeDBiQ6FHL3.

Family and domain databases

InterProiIPR006634. TLC-dom.
IPR013599. TRAM1.
IPR016447. Translocation_assoc_membrane.
[Graphical view]
PfamiPF08390. TRAM1. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005449. Translocation_assoc_membrane. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FHL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRKKSTKS PPVLSHEFVL QNHADIVSCV AMVFLLGLMF EITAKASIIF
60 70 80 90 100
VTLQYNVTLP ATEEQATESV SLYYYGIKDL ATVFFYMLVA IIIHAVIQEY
110 120 130 140 150
MLDKINRRMH FSKTKHSKFN ESGQLSAFYL FACVWGTFIL ISENYISDPT
160 170 180 190 200
ILWRAYPHNL MTFQMKFFYI SQLAYWLHAF PELYFQKTKK EDIPRQLVYI
210 220 230 240 250
GLYLFHIAGA YLLNLNHLGL VLLVLHYFVE FLFHISRLFY FSNEKYQKGF
260 270 280 290 300
SLWAVLFVLG RLLTLILSVL TVGFGLARAE NQKLDFSTGN FNVLAVRIAV
310 320 330 340 350
LASICVTQAF MMWKFINFQL RRWREHSAFQ APAVKKKPTV TKGRSSKKGT
360 370
ENGVNGTLTS NVADSPRNKK EKSS
Length:374
Mass (Da):43,072
Last modified:May 10, 2005 - v1
Checksum:i9232ADA33DE20076
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007359 mRNA. Translation: AAP36023.1.
AK292777 mRNA. Translation: BAF85466.1.
CR541739 mRNA. Translation: CAG46539.1.
CH471068 Genomic DNA. Translation: EAW86967.1.
CH471068 Genomic DNA. Translation: EAW86968.1.
RefSeqiNP_055109.1. NM_014294.5.
UniGeneiHs.491988.

Genome annotation databases

GeneIDi23471.
KEGGihsa:23471.
UCSCiuc003xyo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007359 mRNA. Translation: AAP36023.1.
AK292777 mRNA. Translation: BAF85466.1.
CR541739 mRNA. Translation: CAG46539.1.
CH471068 Genomic DNA. Translation: EAW86967.1.
CH471068 Genomic DNA. Translation: EAW86968.1.
RefSeqiNP_055109.1. NM_014294.5.
UniGeneiHs.491988.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000262213.

Proteomic databases

MaxQBiQ6FHL3.

Protocols and materials databases

DNASUi23471.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23471.
KEGGihsa:23471.
UCSCiuc003xyo.3. human.

Organism-specific databases

CTDi23471.
PharmGKBiPA134955644.

Phylogenomic databases

eggNOGiKOG1608. Eukaryota.
ENOG410XSB3. LUCA.
HOVERGENiHBG054402.
KOiK14010.
OMAiLQLAYWF.
OrthoDBiEOG091G077N.
PhylomeDBiQ6FHL3.

Miscellaneous databases

ChiTaRSiTRAM1. human.
GenomeRNAii23471.

Gene expression databases

BgeeiENSG00000067167.

Family and domain databases

InterProiIPR006634. TLC-dom.
IPR013599. TRAM1.
IPR016447. Translocation_assoc_membrane.
[Graphical view]
PfamiPF08390. TRAM1. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005449. Translocation_assoc_membrane. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FHL3_HUMAN
AccessioniPrimary (citable) accession number: Q6FHL3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.