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Protein
Submitted name:

POMC protein

Gene

POMC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Submitted name:
POMC proteinImported
Gene namesi
Name:POMCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33526.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 267241Sequence analysisPRO_5004273420Add
BLAST

Proteomic databases

PaxDbiQ6FHC8.
PRIDEiQ6FHC8.

PTM databases

iPTMnetiQ6FHC8.

Expressioni

Gene expression databases

GenevisibleiQ6FHC8. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000264708.

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IKR5. Eukaryota.
ENOG410Z5R4. LUCA.
HOVERGENiHBG004341.
KOiK05228.

Family and domain databases

InterProiIPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
[Graphical view]
PfamiPF00976. ACTH_domain. 3 hits.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
[Graphical view]
PRINTSiPR00383. MELANOCORTIN.
SMARTiSM01363. ACTH_domain. 2 hits.
SM01364. NPP. 1 hit.
SM01365. Op_neuropeptide. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6FHC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSCCSRSG ALLLALLLQA SMEVRGWCLE SSQCQDLTTE SNLLECIRAC
60 70 80 90 100
KPDLSAETPM FPGNGDEQPL TENPRKYVMG HFRWDRFGRR NSSSSGSSGA
110 120 130 140 150
GQKREDVSAG EDCGPLPEGG PEPRSDGAKP GPREGKRSYS MEHFRWGKPV
160 170 180 190 200
GKKRRPVKVY PNGADDESAE AFPLEFKREL TGQRLREGDG PDGPADDGAG
210 220 230 240 250
AQADLEHSLL VAAEKKDEGP YRMEHFRWGS PPKDKRYGGF MTSEKSQTPL
260
VTLFKNAIIK NAYKKGE
Length:267
Mass (Da):29,410
Last modified:July 19, 2004 - v1
Checksum:i4D76772024B3749C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei267 – 2671Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR541826 mRNA. Translation: CAG46625.1.
UniGeneiHs.1897.

Genome annotation databases

KEGGihsa:5443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR541826 mRNA. Translation: CAG46625.1.
UniGeneiHs.1897.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000264708.

PTM databases

iPTMnetiQ6FHC8.

Proteomic databases

PaxDbiQ6FHC8.
PRIDEiQ6FHC8.

Protocols and materials databases

DNASUi5443.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGihsa:5443.

Organism-specific databases

CTDi5443.
PharmGKBiPA33526.

Phylogenomic databases

eggNOGiENOG410IKR5. Eukaryota.
ENOG410Z5R4. LUCA.
HOVERGENiHBG004341.
KOiK05228.

Miscellaneous databases

ChiTaRSiPOMC. human.
GenomeRNAii5443.
NextBioi21063.

Gene expression databases

GenevisibleiQ6FHC8. HS.

Family and domain databases

InterProiIPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
[Graphical view]
PfamiPF00976. ACTH_domain. 3 hits.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
[Graphical view]
PRINTSiPR00383. MELANOCORTIN.
SMARTiSM01363. ACTH_domain. 2 hits.
SM01364. NPP. 1 hit.
SM01365. Op_neuropeptide. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6FHC8_HUMAN
AccessioniPrimary (citable) accession number: Q6FHC8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: May 11, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.