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Protein
Submitted name:

CSF3 protein

Gene

CSF3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
CSF3 proteinImported
Submitted name:
Colony stimulating factor 3 (Granulocyte), isoform CRA_cImported
Submitted name:
cDNA, FLJ94067, Homo sapiens colony stimulating factor 3 (granulocyte) (CSF3),transcript variant 2, mRNAImported
Gene namesi
Name:CSF3Imported
ORF Names:hCG_30013Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26941.

Protein family/group databases

Allergomei8367. Hom s G-CSF.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_500770816631 – 204Sequence analysisAdd BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi66 ↔ 72UniRule annotation
Disulfide bondi94 ↔ 104UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000108342.
ExpressionAtlasiQ6FH65. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000225474.

Structurei

3D structure databases

ProteinModelPortaliQ6FH65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IIM2. Eukaryota.
ENOG4111DA4. LUCA.
HOGENOMiHOG000015371.
HOVERGENiHBG005411.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PfamiPF16647. GCSF. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6FH65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPATQSPM KLMALQLLLW HSALWTVQEA TPLGPASSLP QSFLLKCLEQ
60 70 80 90 100
VRKIQGDGAA LQEKLCATYK LCHPEELVLL GHSLGIPWAP LSSCPSQALQ
110 120 130 140 150
LAGCLSQLHS GLFLYQGLLQ ALEGISPELG PTLDTLQLDV ADFATTIWQQ
160 170 180 190 200
MEELGMAPAL QPTQGAMPAF ASAFQRRAGG VLVASHLQSF LEVSYRVLRH

LAQP
Length:204
Mass (Da):21,978
Last modified:May 10, 2005 - v1
Checksum:i5F07C52F13D6A6D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei204Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313509 mRNA. Translation: BAG36289.1.
CR541891 mRNA. Translation: CAG46689.1.
CH471152 Genomic DNA. Translation: EAW60628.1.
RefSeqiNP_757373.1. NM_172219.2.
UniGeneiHs.2233.

Genome annotation databases

GeneIDi1440.
UCSCiuc002hto.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313509 mRNA. Translation: BAG36289.1.
CR541891 mRNA. Translation: CAG46689.1.
CH471152 Genomic DNA. Translation: EAW60628.1.
RefSeqiNP_757373.1. NM_172219.2.
UniGeneiHs.2233.

3D structure databases

ProteinModelPortaliQ6FH65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000225474.

Protein family/group databases

Allergomei8367. Hom s G-CSF.

Protocols and materials databases

DNASUi1440.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1440.
UCSCiuc002hto.3. human.

Organism-specific databases

CTDi1440.
PharmGKBiPA26941.

Phylogenomic databases

eggNOGiENOG410IIM2. Eukaryota.
ENOG4111DA4. LUCA.
HOGENOMiHOG000015371.
HOVERGENiHBG005411.

Miscellaneous databases

GenomeRNAii1440.

Gene expression databases

BgeeiENSG00000108342.
ExpressionAtlasiQ6FH65. baseline and differential.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PfamiPF16647. GCSF. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FH65_HUMAN
AccessioniPrimary (citable) accession number: Q6FH65
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.