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Protein
Submitted name:

ASPA protein

Gene

ASPA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi21ZincUniRule annotation1
Metal bindingi24ZincUniRule annotation1
Binding sitei63SubstrateUniRule annotation1
Metal bindingi116ZincUniRule annotation1
Active sitei178UniRule annotation1
Binding sitei178SubstrateUniRule annotation1
Binding sitei288SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
ASPA proteinImported
Submitted name:
Aspartoacylase (Canavan disease), isoform CRA_aImported
Submitted name:
cDNA, FLJ93347, Homo sapiens aspartoacylase (aminoacylase 2, Canavan disease)(ASPA), mRNAImported
Gene namesi
Name:ASPAImported
ORF Names:hCG_32633Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000108381.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25055

Expressioni

Gene expression databases

BgeeiENSG00000108381
ExpressionAtlasiQ6FH48 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ6FH48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 71Substrate bindingUniRule annotation2
Regioni164 – 168Substrate bindingUniRule annotation5

Phylogenomic databases

eggNOGiENOG410IERR Eukaryota
COG2988 LUCA
HOVERGENiHBG004172
KOiK01437
OMAiVYKIMEK
OrthoDBiEOG091G0BL6

Family and domain databases

CDDicd06909 M14_ASPA, 1 hit
HAMAPiMF_00704 Aspartoacylase, 1 hit
InterProiView protein in InterPro
IPR016708 Aspartoacylase
IPR007036 Aste_AspA
PfamiView protein in Pfam
PF04952 AstE_AspA, 1 hit
PIRSFiPIRSF018001 Aspartoacylase, 1 hit

Sequencei

Sequence statusi: Fragment.

Q6FH48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSCHIAEEH IQKVAIFGGT HGNELTGVFL VKHWLENGAE IQRTGLEVKP
60 70 80 90 100
FITNPRAVKK CTRYIDCDLN RIFDLENLGK KMSEDLPYEV RRAQEINHLF
110 120 130 140 150
GPKDSEDSYD IIFDLHNTTS NMGCTLILED SRNNFLIQMF HYIKTSLAPL
160 170 180 190 200
PCYVYLIEHP SLKYATTRSI AKYPVGIEVG PQPQGVLRAD ILDQMRKMIK
210 220 230 240 250
HALDFIHHFN EGKEFPPCAI EVYKIIEKVD YPRDENGEIA AIIHPNLQDQ
260 270 280 290 300
DWKPLHPGDP MFLTLDGKTI PLGGDCTVYP VFVNEAAYYE KKEAFAKTTK
310
LTLNAKSIRC CLH
Length:313
Mass (Da):35,735
Last modified:May 10, 2005 - v1
Checksum:i33C0B9B07839E7F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei313Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312901 mRNA Translation: BAG35747.1
CR541908 mRNA Translation: CAG46706.1
CH471108 Genomic DNA Translation: EAW90506.1
RefSeqiNP_000040.1, NM_000049.2
NP_001121557.1, NM_001128085.1
XP_016880150.1, XM_017024661.1
UniGeneiHs.171142

Genome annotation databases

GeneIDi443
KEGGihsa:443
UCSCiuc002fvq.4 human

Similar proteinsi

Entry informationi

Entry nameiQ6FH48_HUMAN
AccessioniPrimary (citable) accession number: Q6FH48
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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