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Protein

Decorin

Gene

DCN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May affect the rate of fibrils formation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
DecorinUniRule annotation
Alternative name(s):
Bone proteoglycan IIUniRule annotation
Gene namesi
Name:DCNImported
Synonyms:DKFZp686J19238Imported
ORF Names:hCG_24110Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000011465.16.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrixUniRule annotation, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16UniRule annotationAdd BLAST16
ChainiPRO_501101801117 – 359DecorinUniRule annotationAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 60UniRule annotation
Disulfide bondi58 ↔ 67UniRule annotation
Disulfide bondi313 ↔ 346UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000011465.

Interactioni

Subunit structurei

Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 85LRRNTInterPro annotationAdd BLAST33

Sequence similaritiesi

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.UniRule annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOVERGENiHBG016052.
KOiK04660.
OMAiPLGPVCP.
OrthoDBiEOG091G044B.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR028549. Decorin.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR016352. SLRP_I_decor/aspor/byglycan.
PANTHERiPTHR44053:SF2. PTHR44053:SF2. 1 hit.
PfamiView protein in Pfam
PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 6 hits.
SM00013. LRRNT. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 8 hits.

Sequencei

Sequence statusi: Complete.

Q6FH10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL
60 70 80 90 100
GPVCPFRCQC HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD
110 120 130 140 150
FKNLKNLHAL ILVNNKISKV SPGAFTPLVK LERLYLSKNQ LKELPEKMPK
160 170 180 190 200
TLQELRAHEN EITKVRKVTF NGLNQMIVIE LGTNPLKSSG IENGAFQGMK
210 220 230 240 250
KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS LKGLNNLAKL
260 270 280 290 300
GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH
310 320 330 340 350
NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR

SAIQLGNYK
Length:359
Mass (Da):39,747
Last modified:May 10, 2005 - v1
Checksum:iFF511E871A1A52DD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei359Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KU178017 mRNA. Translation: ALQ33475.1.
AK291309 mRNA. Translation: BAF83998.1.
BX571756 mRNA. Translation: CAE11881.1.
CR407676 mRNA. Translation: CAG28604.1.
CR541946 mRNA. Translation: CAG46744.1.
CH471054 Genomic DNA. Translation: EAW97451.1.
CH471054 Genomic DNA. Translation: EAW97452.1.
CH471054 Genomic DNA. Translation: EAW97457.1.
CH471054 Genomic DNA. Translation: EAW97459.1.
RefSeqiNP_001911.1. NM_001920.4.
NP_598010.1. NM_133503.3.
NP_598011.1. NM_133504.3.
NP_598012.1. NM_133505.3.
NP_598013.1. NM_133506.3.
NP_598014.1. NM_133507.3.
XP_005268750.1. XM_005268693.1.
XP_006719333.1. XM_006719270.1.
XP_016874406.1. XM_017018917.1.
UniGeneiHs.156316.
Hs.530910.

Genome annotation databases

GeneIDi1634.
KEGGihsa:1634.
UCSCiuc001tbt.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ6FH10_HUMAN
AccessioniPrimary (citable) accession number: Q6FH10
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 25, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.