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Protein
Submitted name:

HPCAL1 protein

Gene

HPCAL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi73 – 84PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi109 – 120PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi157 – 168PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
HPCAL1 proteinImported
Submitted name:
Hippocalcin-like 1Imported
Submitted name:
Hippocalcin-like 1, isoform CRA_aImported
Submitted name:
Putative uncharacterized protein HPCAL1Imported
Submitted name:
cDNA FLJ78291, highly similar to Homo sapiens hippocalcin-like 1 (HPCAL1), transcript variant 2, mRNAImported
Gene namesi
Name:HPCAL1Imported
ORF Names:hCG_23828Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29418.

PTM / Processingi

Proteomic databases

MaxQBiQ6FGY1.

Expressioni

Gene expression databases

BgeeiENSG00000115756.
ExpressionAtlasiQ6FGY1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310749.

Structurei

3D structure databases

SMRiQ6FGY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 58EF-handInterPro annotationAdd BLAST18
Domaini60 – 95EF-handInterPro annotationAdd BLAST36
Domaini96 – 131EF-handInterPro annotationAdd BLAST36
Domaini144 – 179EF-handInterPro annotationAdd BLAST36

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
HOVERGENiHBG108179.
OMAiLEIVQXK.
OrthoDBiEOG091G11T4.
PhylomeDBiQ6FGY1.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 3 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Q6FGY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK
60 70 80 90 100
IYANFFPYGD ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISRSE MLEIVQAIYK MVSSVMKMPE DESTPEKRTD
160 170 180 190
KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF
Length:193
Mass (Da):22,313
Last modified:May 10, 2005 - v1
Checksum:i87DCE938DCAD5E1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009835 mRNA. Translation: AAP88837.1.
AC007249 Genomic DNA. Translation: AAY15033.1.
AK292280 mRNA. Translation: BAF84969.1.
CR541975 mRNA. Translation: CAG46773.1.
CH471053 Genomic DNA. Translation: EAX00960.1.
CH471053 Genomic DNA. Translation: EAX00961.1.
CH471053 Genomic DNA. Translation: EAX00962.1.
CH471053 Genomic DNA. Translation: EAX00964.1.
CH471053 Genomic DNA. Translation: EAX00965.1.
CH471053 Genomic DNA. Translation: EAX00966.1.
RefSeqiNP_001245286.1. NM_001258357.1.
NP_001245287.1. NM_001258358.1.
NP_001245288.1. NM_001258359.1.
NP_002140.2. NM_002149.3.
NP_602293.1. NM_134421.2.
XP_005246217.1. XM_005246160.1.
XP_005246218.1. XM_005246161.1.
XP_005246219.1. XM_005246162.1.
XP_005246220.1. XM_005246163.1.
XP_011508648.1. XM_011510346.2.
XP_011508649.1. XM_011510347.1.
XP_011508650.1. XM_011510348.1.
XP_016859439.1. XM_017003950.1.
XP_016859440.1. XM_017003951.1.
XP_016859441.1. XM_017003952.1.
XP_016859442.1. XM_017003953.1.
UniGeneiHs.580427.
Hs.741268.

Genome annotation databases

GeneIDi3241.
KEGGihsa:3241.
UCSCiuc002raj.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009835 mRNA. Translation: AAP88837.1.
AC007249 Genomic DNA. Translation: AAY15033.1.
AK292280 mRNA. Translation: BAF84969.1.
CR541975 mRNA. Translation: CAG46773.1.
CH471053 Genomic DNA. Translation: EAX00960.1.
CH471053 Genomic DNA. Translation: EAX00961.1.
CH471053 Genomic DNA. Translation: EAX00962.1.
CH471053 Genomic DNA. Translation: EAX00964.1.
CH471053 Genomic DNA. Translation: EAX00965.1.
CH471053 Genomic DNA. Translation: EAX00966.1.
RefSeqiNP_001245286.1. NM_001258357.1.
NP_001245287.1. NM_001258358.1.
NP_001245288.1. NM_001258359.1.
NP_002140.2. NM_002149.3.
NP_602293.1. NM_134421.2.
XP_005246217.1. XM_005246160.1.
XP_005246218.1. XM_005246161.1.
XP_005246219.1. XM_005246162.1.
XP_005246220.1. XM_005246163.1.
XP_011508648.1. XM_011510346.2.
XP_011508649.1. XM_011510347.1.
XP_011508650.1. XM_011510348.1.
XP_016859439.1. XM_017003950.1.
XP_016859440.1. XM_017003951.1.
XP_016859441.1. XM_017003952.1.
XP_016859442.1. XM_017003953.1.
UniGeneiHs.580427.
Hs.741268.

3D structure databases

SMRiQ6FGY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310749.

Proteomic databases

MaxQBiQ6FGY1.

Protocols and materials databases

DNASUi3241.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3241.
KEGGihsa:3241.
UCSCiuc002raj.5. human.

Organism-specific databases

CTDi3241.
PharmGKBiPA29418.

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
HOVERGENiHBG108179.
OMAiLEIVQXK.
OrthoDBiEOG091G11T4.
PhylomeDBiQ6FGY1.

Miscellaneous databases

ChiTaRSiHPCAL1. human.
GenomeRNAii3241.

Gene expression databases

BgeeiENSG00000115756.
ExpressionAtlasiQ6FGY1. baseline and differential.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 3 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FGY1_HUMAN
AccessioniPrimary (citable) accession number: Q6FGY1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: March 15, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.