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Protein
Submitted name:

TIMP metallopeptidase inhibitor 1, isoform CRA_a

Gene

TIMP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
TIMP metallopeptidase inhibitor 1, isoform CRA_aImported
Submitted name:
TIMP1 proteinImported
Submitted name:
cDNA, FLJ92204, Homo sapiens tissue inhibitor of metalloproteinase 1 (erythroidpotentiating activity, collagenase inhibitor) (TIMP1), mRNAImported
Gene namesi
Name:TIMP1Imported
ORF Names:hCG_29141Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36526.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501014189724 – 207Sequence analysisAdd BLAST184

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ6FGX5.

Expressioni

Gene expression databases

BgeeiENSG00000102265.
ExpressionAtlasiQ6FGX5. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ6FGX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 147NTRInterPro annotationAdd BLAST124

Keywords - Domaini

CollagenImported, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4745. Eukaryota.
ENOG41103NU. LUCA.
HOVERGENiHBG068749.
KOiK16451.
OMAiDTHCLWT.
OrthoDBiEOG091G0NIC.

Family and domain databases

Gene3Di3.90.370.10. 1 hit.
InterProiView protein in InterPro
IPR001134. Netrin_domain.
IPR001820. TIMP.
IPR008993. TIMP-like_OB-fold.
IPR015611. TIMP1.
IPR027465. TIMP_C.
IPR030490. TIMP_CS.
PANTHERiPTHR11844. PTHR11844. 1 hit.
PTHR11844:SF29. PTHR11844:SF29. 1 hit.
PfamiView protein in Pfam
PF00965. TIMP. 1 hit.
SMARTiView protein in SMART
SM00206. NTR. 1 hit.
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiView protein in PROSITE
PS50189. NTR. 1 hit.
PS00288. TIMP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FGX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPFEPLASG ILLLLWLIAP SRACTCVPPH PQTAFCNSDL VIRAKFVGTP
60 70 80 90 100
EVNQTTLYQR YEIKMTKMYK GFQALGDAAD IRFVYTPAME SVCGYFHRSH
110 120 130 140 150
NRSEEFLIAG KLQDGLLHIT TCSFVAPWNS LSLAQRRGFT KTYTVGCEEC
160 170 180 190 200
TVFPCLSIPC KLQSGTHCLW TDQLLQGSEK GFQSRHLACL PREPGLCTWQ

SLRSQIA
Length:207
Mass (Da):23,171
Last modified:May 10, 2005 - v1
Checksum:i5AE4F90FFAB2ECDC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei207Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311937 mRNA. Translation: BAG34878.1.
CR407638 mRNA. Translation: CAG28566.1.
CR541982 mRNA. Translation: CAG46779.1.
CH471164 Genomic DNA. Translation: EAW59315.1.
RefSeqiNP_003245.1. NM_003254.2.
UniGeneiHs.522632.

Genome annotation databases

GeneIDi7076.
KEGGihsa:7076.
UCSCiuc004dif.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ6FGX5_HUMAN
AccessioniPrimary (citable) accession number: Q6FGX5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: July 5, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.