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Protein
Submitted name:

IL10 protein

Gene

IL10

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
IL10 proteinImported
Submitted name:
Interleukin 10Imported
Gene namesi
Name:IL10Imported
ORF Names:hCG_22208Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 178160Sequence analysisPRO_5007708493Add
BLAST

Expressioni

Gene expression databases

BgeeiENSG00000136634.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000412237.

Structurei

3D structure databases

SMRiQ6FGW4. Positions 24-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IYFW. Eukaryota.
ENOG4111PXC. LUCA.
HOVERGENiHBG004110.
KOiK05443.
OMAiPHMLREL.
OrthoDBiEOG091G0Y3M.
PhylomeDBiQ6FGW4.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FGW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSSALLCCL VLLTGVRASP GQGTQSENSC THFPGNLPNM LRDLRDAFSR
60 70 80 90 100
VKTFFQMKDQ LDNLLLKESL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN
110 120 130 140 150
QDPDIKAHVN SLGENLKTLR LRLRRCHRFL PCENKSKAVE QVKNAFNKLQ
160 170
EKGIYKAMSE FDIFINYIEA YMTMKIRN
Length:178
Mass (Da):20,517
Last modified:May 10, 2005 - v1
Checksum:i6825E9FA4337CDE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104252 mRNA. Translation: AAI04253.1.
BC104253 mRNA. Translation: AAI04254.1.
DQ217938 Genomic DNA. Translation: ABB01008.1.
GQ405199 Genomic DNA. Translation: ACV30066.1.
CR541993 mRNA. Translation: CAG46790.1.
CH471100 Genomic DNA. Translation: EAW93524.1.
RefSeqiNP_000563.1. NM_000572.2.
UniGeneiHs.193717.

Genome annotation databases

GeneIDi3586.
KEGGihsa:3586.
UCSCiuc001hen.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104252 mRNA. Translation: AAI04253.1.
BC104253 mRNA. Translation: AAI04254.1.
DQ217938 Genomic DNA. Translation: ABB01008.1.
GQ405199 Genomic DNA. Translation: ACV30066.1.
CR541993 mRNA. Translation: CAG46790.1.
CH471100 Genomic DNA. Translation: EAW93524.1.
RefSeqiNP_000563.1. NM_000572.2.
UniGeneiHs.193717.

3D structure databases

SMRiQ6FGW4. Positions 24-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000412237.

Protocols and materials databases

DNASUi3586.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3586.
KEGGihsa:3586.
UCSCiuc001hen.2. human.

Organism-specific databases

CTDi3586.
PharmGKBiPA29778.

Phylogenomic databases

eggNOGiENOG410IYFW. Eukaryota.
ENOG4111PXC. LUCA.
HOVERGENiHBG004110.
KOiK05443.
OMAiPHMLREL.
OrthoDBiEOG091G0Y3M.
PhylomeDBiQ6FGW4.

Miscellaneous databases

GenomeRNAii3586.

Gene expression databases

BgeeiENSG00000136634.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FGW4_HUMAN
AccessioniPrimary (citable) accession number: Q6FGW4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.