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Protein
Submitted name:

HCG2025883, isoform CRA_b

Gene

POLR2C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
HCG2025883, isoform CRA_bImported
Submitted name:
POLR2C proteinImported
Submitted name:
cDNA FLJ76636, highly similar to Homo sapiens polymerase (RNA) II (DNA directed) polypeptide C, 33kDa (POLR2C), transcript variant alpha, mRNAImported
Gene namesi
Name:POLR2CImported
ORF Names:hCG_2025883Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000102978.12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33509

PTM / Processingi

Proteomic databases

MaxQBiQ6FGR6
PRIDEiQ6FGR6

Expressioni

Gene expression databases

BgeeiENSG00000102978
ExpressionAtlasiQ6FGR6 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6FGR6, 1 interactor

Structurei

3D structure databases

SMRiQ6FGR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 262RPOLDInterPro annotationAdd BLAST245

Phylogenomic databases

eggNOGiKOG1522 Eukaryota
COG0202 LUCA
HOVERGENiHBG000897
KOiK03011
OMAiMAIDWVQ
OrthoDBiEOG091G0EGB

Family and domain databases

Gene3Di2.170.120.12, 1 hit
3.30.1360.10, 2 hits
InterProiView protein in InterPro
IPR001514 DNA-dir_RNA_pol_30-40kDasu_CS
IPR011262 DNA-dir_RNA_pol_insert
IPR011263 DNA-dir_RNA_pol_RpoA/D/Rpb3
IPR036603 RBP11-like
IPR036643 RNApol_insert_sf
PfamiView protein in Pfam
PF01000 RNA_pol_A_bac, 1 hit
PF01193 RNA_pol_L, 1 hit
SMARTiView protein in SMART
SM00662 RPOLD, 1 hit
SUPFAMiSSF55257 SSF55257, 2 hits
SSF56553 SSF56553, 1 hit
PROSITEiView protein in PROSITE
PS00446 RNA_POL_D_30KD, 1 hit

Sequencei

Sequence statusi: Complete.

Q6FGR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYANQPTVR ITELTDENVK FIIENTDLAV ANSIRRVFIA EVPIIAIDWV
60 70 80 90 100
QIDANSSVLH DEFIAHRLGL IPLISDDIVD KLQYSRDCTC EEFCPECSVE
110 120 130 140 150
FTLDVRCNED QTRHVTSRDL ISNSPRVIPV TSRNRDNDPN DYVEQDDILI
160 170 180 190 200
VKLRKGQELR LRAYAKKGFG KEHAKWNPTA GVAFEYDPDN ALRHTVYPKP
210 220 230 240 250
EEWPKSEYSE LDEDESQAPY DPNGKPERFY YNVESCGSLR PETIVLSALS
260 270
GLKKKLSDLQ TQLSHEIQSD VLTIN
Length:275
Mass (Da):31,441
Last modified:May 10, 2005 - v1
Checksum:iEF663BE096046A4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293112 mRNA Translation: BAF85801.1
CR542041 mRNA Translation: CAG46838.1
CH471092 Genomic DNA Translation: EAW82926.1
CH471092 Genomic DNA Translation: EAW82927.1
CH471092 Genomic DNA Translation: EAW82929.1
CH471092 Genomic DNA Translation: EAW82930.1
RefSeqiNP_116558.1, NM_032940.2
UniGeneiHs.79402

Genome annotation databases

GeneIDi5432
KEGGihsa:5432
UCSCiuc002elt.2 human

Similar proteinsi

Entry informationi

Entry nameiQ6FGR6_HUMAN
AccessioniPrimary (citable) accession number: Q6FGR6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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