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Protein
Submitted name:

SH3-domain GRB2-like 1

Gene

SH3GL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
SH3-domain GRB2-like 1Imported
Submitted name:
SH3-domain GRB2-like 1, isoform CRA_bImported
Submitted name:
SH3GL1 proteinImported
Submitted name:
cDNA, FLJ96508, Homo sapiens SH3-domain GRB2-like 1 (SH3GL1), mRNAImported
Gene namesi
Name:SH3GL1Imported
ORF Names:hCG_21932Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000141985.9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35736

PTM / Processingi

Proteomic databases

PRIDEiQ6FGM0

Expressioni

Gene expression databases

BgeeiENSG00000141985
ExpressionAtlasiQ6FGM0 baseline and differential

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6FGM0, 9 interactors

Structurei

3D structure databases

SMRiQ6FGM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 249BARInterPro annotationAdd BLAST232
Domaini306 – 365SH3InterPro annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili180 – 207Sequence analysisAdd BLAST28
Coiled coili230 – 250Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1118 Eukaryota
ENOG410XNYB LUCA
HOVERGENiHBG052866
KOiK11247
OMAiIRGQVKN
OrthoDBiEOG091G16FW

Family and domain databases

CDDicd11803 SH3_Endophilin_A, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR004148 BAR_dom
IPR028501 Endophilin-A
IPR035824 Endophilin_A_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR43965 PTHR43965, 1 hit
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6FGM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKEMEKKV DVTSKAVTEV
60 70 80 90 100
LARTIEYLQP NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMIRH
110 120 130 140 150
GKELGGESNF GDALLDAGES MKRLAEVKDS LDIEVKQNFI DPLQNLCEKD
160 170 180 190 200
LKEIQHHLKK LEGRRLDFDY KKKRQGKIPD EELRQALEKF EESKEVAETS
210 220 230 240 250
MHNLLETDIE QVSQLSALVD AQLDYHRQAV QILDELAEKL KRRMREASSR
260 270 280 290 300
PKREYKPKPR EPFDLGEPEQ SNGGFPCTTA PKIAASSSFR SSDKPIRTPS
310 320 330 340 350
RSMPPLDQPS CKALYDFEPE NDGELGFHEG DVITLTNQID ENWYEGMLDG
360
QSGFFPLSYV EVLVPLPQ
Length:368
Mass (Da):41,490
Last modified:May 10, 2005 - v1
Checksum:i6E5BE978BC955077
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098565 mRNA Translation: AAH98565.1
AY364240 mRNA Translation: AAQ76799.1
AK315450 mRNA Translation: BAG37838.1
CR542087 mRNA Translation: CAG46884.1
CH471139 Genomic DNA Translation: EAW69228.1
CH471139 Genomic DNA Translation: EAW69229.1
RefSeqiNP_003016.1, NM_003025.3
UniGeneiHs.490415
Hs.97616

Genome annotation databases

GeneIDi6455
KEGGihsa:6455

Similar proteinsi

Entry informationi

Entry nameiQ6FGM0_HUMAN
AccessioniPrimary (citable) accession number: Q6FGM0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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