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Protein
Submitted name:

SH3 domain GRB2-like 1

Gene

SH3GL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
SH3 domain GRB2-like 1Imported
Submitted name:
SH3-domain GRB2-like 1Imported
Submitted name:
SH3-domain GRB2-like 1, isoform CRA_bImported
Submitted name:
SH3GL1 proteinImported
Submitted name:
cDNA, FLJ96508, Homo sapiens SH3-domain GRB2-like 1 (SH3GL1), mRNAImported
Gene namesi
Name:SH3GL1Imported
ORF Names:hCG_21932Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35736.

Expressioni

Gene expression databases

BgeeiENSG00000141985.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6FGM0. 9 interactors.
MINTiMINT-1399112.
STRINGi9606.ENSP00000269886.

Structurei

3D structure databases

SMRiQ6FGM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 249BARInterPro annotationAdd BLAST232
Domaini306 – 365SH3InterPro annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili180 – 207Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1118. Eukaryota.
ENOG410XNYB. LUCA.
HOVERGENiHBG052866.
KOiK11247.
OMAiIRGQVKN.
OrthoDBiEOG091G16FW.

Family and domain databases

InterProiView protein in InterPro
IPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF03114. BAR. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF103657. SSF103657. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FGM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKEMEKKV DVTSKAVTEV
60 70 80 90 100
LARTIEYLQP NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMIRH
110 120 130 140 150
GKELGGESNF GDALLDAGES MKRLAEVKDS LDIEVKQNFI DPLQNLCEKD
160 170 180 190 200
LKEIQHHLKK LEGRRLDFDY KKKRQGKIPD EELRQALEKF EESKEVAETS
210 220 230 240 250
MHNLLETDIE QVSQLSALVD AQLDYHRQAV QILDELAEKL KRRMREASSR
260 270 280 290 300
PKREYKPKPR EPFDLGEPEQ SNGGFPCTTA PKIAASSSFR SSDKPIRTPS
310 320 330 340 350
RSMPPLDQPS CKALYDFEPE NDGELGFHEG DVITLTNQID ENWYEGMLDG
360
QSGFFPLSYV EVLVPLPQ
Length:368
Mass (Da):41,490
Last modified:May 10, 2005 - v1
Checksum:i6E5BE978BC955077
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098565 mRNA. Translation: AAH98565.1.
AY364240 mRNA. Translation: AAQ76799.1.
AK315450 mRNA. Translation: BAG37838.1.
CR542087 mRNA. Translation: CAG46884.1.
CH471139 Genomic DNA. Translation: EAW69228.1.
CH471139 Genomic DNA. Translation: EAW69229.1.
RefSeqiNP_003016.1. NM_003025.3.
UniGeneiHs.490415.
Hs.97616.

Genome annotation databases

GeneIDi6455.
KEGGihsa:6455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098565 mRNA. Translation: AAH98565.1.
AY364240 mRNA. Translation: AAQ76799.1.
AK315450 mRNA. Translation: BAG37838.1.
CR542087 mRNA. Translation: CAG46884.1.
CH471139 Genomic DNA. Translation: EAW69228.1.
CH471139 Genomic DNA. Translation: EAW69229.1.
RefSeqiNP_003016.1. NM_003025.3.
UniGeneiHs.490415.
Hs.97616.

3D structure databases

SMRiQ6FGM0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6FGM0. 9 interactors.
MINTiMINT-1399112.
STRINGi9606.ENSP00000269886.

Protocols and materials databases

DNASUi6455.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6455.
KEGGihsa:6455.

Organism-specific databases

CTDi6455.
PharmGKBiPA35736.

Phylogenomic databases

eggNOGiKOG1118. Eukaryota.
ENOG410XNYB. LUCA.
HOVERGENiHBG052866.
KOiK11247.
OMAiIRGQVKN.
OrthoDBiEOG091G16FW.

Miscellaneous databases

ChiTaRSiSH3GL1. human.
GenomeRNAii6455.

Gene expression databases

BgeeiENSG00000141985.

Family and domain databases

InterProiView protein in InterPro
IPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF03114. BAR. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF103657. SSF103657. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FGM0_HUMAN
AccessioniPrimary (citable) accession number: Q6FGM0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: June 7, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.