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Protein

Glutathione S-transferase

Gene

GSTM3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferaseUniRule annotation (EC:2.5.1.18UniRule annotation)
Gene namesi
Name:GSTM3Imported
ORF Names:hCG_40244Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29024.

Expressioni

Gene expression databases

BgeeiENSG00000134202.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000256594.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 92GST N-terminalInterPro annotationAdd BLAST88
Domaini94 – 212GST C-terminalInterPro annotationAdd BLAST119

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.UniRule annotation
Contains 1 GST C-terminal domain.UniRule annotation
Contains 1 GST N-terminal domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IN5J. Eukaryota.
ENOG4110YU0. LUCA.
HOVERGENiHBG106842.
KOiK00799.
OMAiQVMDFRM.
OrthoDBiEOG091G0K2E.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FGJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCESSMVLG YWDIRGLAHA IRLLLEFTDT SYEEKRYTCG EAPDYDRSQW
60 70 80 90 100
LDVKFKLDLD FPNLPYLLDG KNKITQSNAI LRYIARKHNM CGETEEEKIR
110 120 130 140 150
VDIIENQVMD FRTQLIRLCY SSDHEKLKPQ YLEELPGQLK QFSMFLGKFS
160 170 180 190 200
WFAGEKLTFV DFLTYDILDQ NRIFDPKCLD EFPNLKAFMC RFEALEKIAA
210 220
YLQSDQFCKM PINNKMAQWG NKPVC
Length:225
Mass (Da):26,560
Last modified:May 10, 2005 - v1
Checksum:i79093161ECEF5396
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU136188 Genomic DNA. Translation: ABV02583.1.
AK313444 mRNA. Translation: BAG36233.1.
CR542108 mRNA. Translation: CAG46905.1.
CH471122 Genomic DNA. Translation: EAW56409.1.
RefSeqiNP_000840.2. NM_000849.4.
UniGeneiHs.2006.

Genome annotation databases

GeneIDi2947.
KEGGihsa:2947.
UCSCiuc001dyo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU136188 Genomic DNA. Translation: ABV02583.1.
AK313444 mRNA. Translation: BAG36233.1.
CR542108 mRNA. Translation: CAG46905.1.
CH471122 Genomic DNA. Translation: EAW56409.1.
RefSeqiNP_000840.2. NM_000849.4.
UniGeneiHs.2006.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000256594.

Protocols and materials databases

DNASUi2947.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2947.
KEGGihsa:2947.
UCSCiuc001dyo.3. human.

Organism-specific databases

CTDi2947.
PharmGKBiPA29024.

Phylogenomic databases

eggNOGiENOG410IN5J. Eukaryota.
ENOG4110YU0. LUCA.
HOVERGENiHBG106842.
KOiK00799.
OMAiQVMDFRM.
OrthoDBiEOG091G0K2E.

Miscellaneous databases

GenomeRNAii2947.

Gene expression databases

BgeeiENSG00000134202.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FGJ9_HUMAN
AccessioniPrimary (citable) accession number: Q6FGJ9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 5, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.