Reviewed, UniProtKB/Swiss-Prot Q6FFS1 (LLDD_ACIAD)

Names and origin

Protein names

Recommended name:
    L-lactate dehydrogenase [cytochrome]
    EC=1.1.2.3

Gene names

Name:	lldD
Ordered Locus Names:	ACIAD0108

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. HAMAP MF_01559
Cofactor	FMN By similarity. HAMAP MF_01559
Sequence similarities	Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. Contains 1 FMN hydroxy acid dehydrogenase domain.

Ontologies

Keywords
Ligand	FMN Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro L-lactate dehydrogenase (cytochrome) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	L-lactate dehydrogenase [cytochrome] HAMAP MF_01559		PRO_0000206329
Regions
	Domain	1 – 380	380	FMN hydroxy acid dehydrogenase
	Nucleotide binding	306 – 330	25	FMN By similarity
Sites
	Active site	275	1	Proton acceptor By similarity
	Binding site	24	1	Substrate Potential
	Binding site	106	1	FMN By similarity
	Binding site	127	1	FMN By similarity
	Binding site	129	1	Substrate By similarity
	Binding site	155	1	FMN By similarity
	Binding site	164	1	Substrate By similarity
	Binding site	251	1	FMN By similarity
	Binding site	278	1	Substrate Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6FFS1-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: AA9BE883DC617973	FASTA	384	42,131
	10 20 30 40 50 60 MIISSSNDYR EAAKRRLPPF LFHYIDGGAY AEYTLKRNVE DLSQIALRQR VLNDMSSLSL 70 80 90 100 110 120 ETKLFNETLS MPVALSPVGL TGMYARRGEV QAAVAADKKG IPFTMSTVSV CPIEEVTPAI 130 140 150 160 170 180 KRPMWFQLYV LRDRGFMKNA LERAKAAGCS TLVFTVDMPV PGARYRDAHS GMSGPNAAMR 190 200 210 220 230 240 RYLQSMMHPQ WAWDVGLLGR PHDLGNISKY LGKTTGLEDY ISWLGSNFDP SISWKDLEWI 250 260 270 280 290 300 REFWDGPMVI KGILDPEDAK DAVRFGADGI VVSNHGGRQL DGVMSSARAM PAIAEAVKGD 310 320 330 340 350 360 LTILADSGIR NGLDVVRMLA LGADSVMLGR AFIYALAAQG GQGVSNLLDL IDKEMRVAMT 370 380 LTGAKTIADI NESCLVEMNK LIQS

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG67086.1.
RefSeq	YP_044908.1.
3D structure databases
SMR	Q6FFS1. Positions 4-377.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FFS1.
Genome annotation databases
GeneID	2881112.
GenomeReviews	Gene locus ACIAD0108 in contig CR543861_GR.
KEGG	aci:ACIAD0108.
NMPDR	fig|62977.3.peg.23.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1304.
HOGENOM	HBG517781.
OMA	WIREFWE.
PhylomeDB	Q6FFS1.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD0108-MONOMER.
Family and domain databases
HAMAP	MF_01559. L-lact_dehydr. [Tree]
InterPro	IPR012133. a-Hydoxy_acid_DH_FMN. IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR008259. FMN_hydac_DH_AS. IPR020920. L-lactate_DHase_cyt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF01070. FMN_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITE	PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LLDD_ACIAD

Accession

Primary (citable) accession number: Q6FFS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	July 19, 2004
Last modified:	January 19, 2010
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)