Reviewed, UniProtKB/Swiss-Prot Q6FFB2 (ARLY_ACIAD)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	ACIAD0283

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 477	477	Argininosuccinate lyase HAMAP MF_00006		PRO_0000137729

Sequences

	Sequence		Length	Mass (Da)
	Q6FFB2-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: FD178630F3E77B45	FASTA	477	52,919
	10 20 30 40 50 60 MTTSSHSSEQ PTSTQTSGMW GGRFTEATDA FVAEFTASVQ FDQRFYKQDI AGSIAHATML 70 80 90 100 110 120 AKVGVLTEAE RDDIIQGLSA IKSEIEAGQF EWRIDLEDVH MNIESRLTQR IGITGKKLHT 130 140 150 160 170 180 GRSRNDQVAT DIRLYLRDEI DDILTILLRL QKGLLGLAAQ NTQTIMPGFT HLQTAQPVTF 190 200 210 220 230 240 GHHLMAWFEM FVRDTERLQD CRKRVNRMPL GSAALAGTTY PIDRAFTAEL LGFEAVSENS 250 260 270 280 290 300 LDAVSDRDFA IEFNAAASLI MMHLSRMSEE LILWTSAQFK FVNIPDRFCT GSSIMPQKKN 310 320 330 340 350 360 PDVPELIRGK SGRVFGDLIS LLTLMKGQPL AYNKDNQEDK EPLFDAIDTV RGSLMAFADM 370 380 390 400 410 420 VPALGPNIEI MREAALRGFS TATDLADYLV KKGVAFRDAH EIVGKAVALG VQEEKDLSEL 430 440 450 460 470 SLEQLQQFSD LITADVFDKA LTLEASVNAR DHIGGTSPKQ VEAAIARAYD RLEKLYA

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR543861 Genomic DNA. Translation: CAG67245.1.
RefSeq	YP_045067.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FFB2.
Genome annotation databases
GeneID	2877980.
GenomeReviews	Gene locus ACIAD0283 in contig CR543861_GR.
KEGG	aci:ACIAD0283.
NMPDR	fig|62977.3.peg.621.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6FFB2.
OMA	ATDTRLY.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD0283-MON.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ACIAD

Accession

Primary (citable) accession number: Q6FFB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)