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Protein

Argininosuccinate lyase

Gene

argH

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciASP62977:G1GJ8-263-MONOMER.
UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:ACIAD0283
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000000430 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001377291 – 477Argininosuccinate lyaseAdd BLAST477

Interactioni

Protein-protein interaction databases

STRINGi62977.ACIAD0283.

Structurei

3D structure databases

ProteinModelPortaliQ6FFB2.
SMRiQ6FFB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7. Bacteria.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiSIMPHKK.
OrthoDBiPOG091H026A.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 2 hits.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiView protein in InterPro
IPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
PANTHERiPTHR43814. PTHR43814. 1 hit.
PfamiView protein in Pfam
PF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiView protein in PROSITE
PS00163. FUMARATE_LYASES. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FFB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSSHSSEQ PTSTQTSGMW GGRFTEATDA FVAEFTASVQ FDQRFYKQDI
60 70 80 90 100
AGSIAHATML AKVGVLTEAE RDDIIQGLSA IKSEIEAGQF EWRIDLEDVH
110 120 130 140 150
MNIESRLTQR IGITGKKLHT GRSRNDQVAT DIRLYLRDEI DDILTILLRL
160 170 180 190 200
QKGLLGLAAQ NTQTIMPGFT HLQTAQPVTF GHHLMAWFEM FVRDTERLQD
210 220 230 240 250
CRKRVNRMPL GSAALAGTTY PIDRAFTAEL LGFEAVSENS LDAVSDRDFA
260 270 280 290 300
IEFNAAASLI MMHLSRMSEE LILWTSAQFK FVNIPDRFCT GSSIMPQKKN
310 320 330 340 350
PDVPELIRGK SGRVFGDLIS LLTLMKGQPL AYNKDNQEDK EPLFDAIDTV
360 370 380 390 400
RGSLMAFADM VPALGPNIEI MREAALRGFS TATDLADYLV KKGVAFRDAH
410 420 430 440 450
EIVGKAVALG VQEEKDLSEL SLEQLQQFSD LITADVFDKA LTLEASVNAR
460 470
DHIGGTSPKQ VEAAIARAYD RLEKLYA
Length:477
Mass (Da):52,919
Last modified:July 19, 2004 - v1
Checksum:iFD178630F3E77B45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR543861 Genomic DNA. Translation: CAG67245.1.
RefSeqiWP_011182010.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG67245; CAG67245; ACIAD0283.
KEGGiaci:ACIAD0283.

Similar proteinsi

Entry informationi

Entry nameiARLY_ACIAD
AccessioniPrimary (citable) accession number: Q6FFB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 19, 2004
Last modified: February 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome