Reviewed, UniProtKB/Swiss-Prot Q6FF44 (TPIS_ACIAD)

Names and origin

Protein names

Recommended name:
    Triosephosphate isomerase
      Short name=TIM
    EC=5.3.1.1
Alternative name(s):
    Triose-phosphate isomerase

Gene names

Name:	tpiA
Ordered Locus Names:	ACIAD0363

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP MF_00147
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00147 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP MF_00147
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis Pentose shunt
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Triosephosphate isomerase HAMAP MF_00147		PRO_0000307419
Sites
	Active site	106	1	Electrophile By similarity
	Active site	179	1	Proton acceptor By similarity
	Binding site	13	1	Substrate By similarity
	Binding site	15	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FF44-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 7FE4E66AD80BFDD9	FASTA	265	28,515
	10 20 30 40 50 60 MSGSTIIPWV VGNWKMNPKQ SDAIQLVQQF KDLLKQQPIS EQYCHVGVAP IAIALTTIQS 70 80 90 100 110 120 ELATANRQVA TVAQDVSRFA GTGAYTGEIS AELLTDSQIR YVLIGHSERR DLLGDHVEIL 130 140 150 160 170 180 KAKLSHALNA GMTVIYCVGE SLEQREQGLA EQIVLQQICD IAPVVSAEQW QHQIVIAYEP 190 200 210 220 230 240 IWAIGTGRTA SPEDAQAIHA KIREGLCQIT PAGSQIALLY GGSVKPENAV ELAACPDING 250 260 ALVGGASLNA ESFYKIAQAF AQTQQ

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR543861 Genomic DNA. Translation: CAG67313.1.
RefSeq	YP_045135.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FF44.
Genome annotation databases
GeneID	2880725.
GenomeReviews	Gene locus ACIAD0363 in contig CR543861_GR.
KEGG	aci:ACIAD0363.
NMPDR	fig|62977.3.peg.879.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6FF44.
OMA	NELVADQ.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD0363-MON.
Family and domain databases
HAMAP	MF_00147. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR000652. Triosephosphate_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21139. Triophos_ismrse. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
ProDom	PD001005. Triophos_ismrse. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00419. tim. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPIS_ACIAD

Accession

Primary (citable) accession number: Q6FF44

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)