Reviewed, UniProtKB/Swiss-Prot Q6FEZ7 (AROE_ACIAD)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	ACIAD0418

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325093
Regions
	Nucleotide binding	126 – 130	5	NADP By similarity
Sites
	Active site	66	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6FEZ7-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 59EB34381BB1AB68	FASTA	262	28,409
	10 20 30 40 50 60 MTKQFAVIGN PIEQSRSPEL HHAFAEKLGI ELNYSKRLAP LDGFEANVKT FFDQGGLGIN 70 80 90 100 110 120 VTVPFKEQAF AMCHQLTERA KIAKAVNTLW IENGQLHGDN TDGQGLVDAI QALNWPLQGT 130 140 150 160 170 180 RILILGAGGA TRGVIYPLVQ AGVTEIVIAN RTQQRAEQLV QDLAGSVSEA TLRVMTLDQL 190 200 210 220 230 240 HGNFDLVINA TSASLSGDAL VLPETLQFKY AYEMAYGKPS SFLDQAKARG VPTTEGFGML 250 260 VGQAIEAFSI WHGVKPNLTD FL

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG67361.1.
RefSeq	YP_045183.1.
3D structure databases
HSSP	HSSP built from PDB template 1NYT based on UniProtKB P15770.
SMR	Q6FEZ7. Positions 3-260.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FEZ7.
Genome annotation databases
GeneID	2878789.
GenomeReviews	Gene locus ACIAD0418 in contig CR543861_GR.
KEGG	aci:ACIAD0418.
NMPDR	fig|62977.3.peg.1020.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	RIAVACP.
PhylomeDB	Q6FEZ7.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD0418-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_ACIAD

Accession

Primary (citable) accession number: Q6FEZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)