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Q6FEQ6 (NTPA_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase

EC=3.6.1.19
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name=NTPase
Gene names
Ordered Locus Names:ACIAD0526
OrganismAcinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]
Taxonomic identifier62977 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.

Subunit structure

Homodimer By similarity. HAMAP MF_01405

Sequence similarities

Belongs to the HAM1 NTPase family.

Sequence caution

The sequence CAG67452.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
PRO_0000178114

Regions

Region16 – 216Substrate binding By similarity
Region79 – 802Substrate binding By similarity

Sites

Metal binding791Magnesium or manganese By similarity
Binding site1691Substrate By similarity
Binding site1891Substrate By similarity
Binding site1951Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FEQ6 [UniParc].

Last modified April 26, 2005. Version 2.
Checksum: 93BBAD9E9CB69622

FASTA21023,177
        10         20         30         40         50         60 
MSAPHWLSQG TLVLASNNKG KITEFEKLFA ELQLPVDVIP QGQLNIPDAI EDGLSFVENA 

        70         80         90        100        110        120 
IIKARHASKI SGKPAIADDS GICVPVLGGA PGIYSARYAG DHGNDAANNE KLLHDLKPFR 

       130        140        150        160        170        180 
NAEQAIQGMF VCVLALVEHA EDPLPQIFQG FWHGEILEQA RGEHGFGYDP LFWLSELKMS 

       190        200        210 
SAEMSKEEKN KISHRGQAMQ RFRESLMTRE 

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References

[1]"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ADP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR543861 Genomic DNA. Translation: CAG67452.1. Different initiation.
RefSeqYP_045274.1. NC_005966.1.

3D structure databases

ProteinModelPortalQ6FEQ6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6FEQ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2881010.
GenomeReviewsGene locus ACIAD0526 in contig CR543861_GR.
KEGGaci:ACIAD0526.
NMPDRfig|62977.3.peg.1289.
PATRIC20738954. VBIAciSp98416_0457.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0127.
HOGENOMHBG697237.
OMAGVYTADW.
PhylomeDBQ6FEQ6.
ProtClustDBPRK00120.

Enzyme and pathway databases

BioCycASP62977:ACIAD0526-MONOMER.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
[Tree]
InterProIPR002637. Ham1p-like.
IPR020922. Nucleoside-triphosphatase.
[Graphical view]
KOK02428.
PANTHERPTHR11067. Ham1p_like. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNTPA_ACIAD
AccessionPrimary (citable) accession number: Q6FEQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: January 25, 2012
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families