Q6FEQ6 (NTPA_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-canonical purine NTP pyrophosphatase
EC=3.6.1.19

Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name=NTPase

Gene names

Ordered Locus Names:

ACIAD0526

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405
Cofactor	Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.
Subunit structure	Homodimer By similarity. HAMAP MF_01405
Sequence similarities	Belongs to the HAM1 NTPase family.
Sequence caution	The sequence CAG67452.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Non-canonical purine NTP pyrophosphatase HAMAP MF_01405		PRO_0000178114
Regions
	Region	16 – 21	6	Substrate binding By similarity
	Region	79 – 80	2	Substrate binding By similarity
Sites
	Metal binding	79	1	Magnesium or manganese By similarity
	Binding site	169	1	Substrate By similarity
	Binding site	189	1	Substrate By similarity
	Binding site	195	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FEQ6 [UniParc]. Last modified April 26, 2005. Version 2. Checksum: 93BBAD9E9CB69622	FASTA	210	23,177
	10 20 30 40 50 60 MSAPHWLSQG TLVLASNNKG KITEFEKLFA ELQLPVDVIP QGQLNIPDAI EDGLSFVENA 70 80 90 100 110 120 IIKARHASKI SGKPAIADDS GICVPVLGGA PGIYSARYAG DHGNDAANNE KLLHDLKPFR 130 140 150 160 170 180 NAEQAIQGMF VCVLALVEHA EDPLPQIFQG FWHGEILEQA RGEHGFGYDP LFWLSELKMS 190 200 210 SAEMSKEEKN KISHRGQAMQ RFRESLMTRE

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ADP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG67452.1. Different initiation.
RefSeq	YP_045274.1. NC_005966.1.
3D structure databases
ProteinModelPortal	Q6FEQ6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FEQ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2881010.
GenomeReviews	Gene locus ACIAD0526 in contig CR543861_GR.
KEGG	aci:ACIAD0526.
NMPDR	fig|62977.3.peg.1289.
PATRIC	20738954. VBIAciSp98416_0457.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0127.
HOGENOM	HBG697237.
OMA	GVYTADW.
PhylomeDB	Q6FEQ6.
ProtClustDB	PRK00120.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD0526-MONOMER.
Family and domain databases
HAMAP	MF_01405. Non_canon_purine_NTPase. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
KO	K02428.
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. TIGR00042. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_ACIAD

Accession

Primary (citable) accession number: Q6FEQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program