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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ack)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciASP62977:G1GJ8-490-MONOMER
UniPathwayiUPA00340; UER00459

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:ACIAD0540
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000000430 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004055441 – 720Phosphate acetyltransferaseAdd BLAST720

Proteomic databases

PRIDEiQ6FEP2

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi62977.ACIAD0540

Structurei

3D structure databases

ProteinModelPortaliQ6FEP2
SMRiQ6FEP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni389 – 720Phosphate acetyltransferaseAdd BLAST332

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiENOG4108DNC Bacteria
COG0280 LUCA
COG0857 LUCA
HOGENOMiHOG000053797
KOiK13788
OMAiTPLMFEY
OrthoDBiPOG091H01MW

Family and domain databases

Gene3Di3.40.1390.20, 1 hit
InterProiView protein in InterPro
IPR010766 DRTGG
IPR016475 P-Actrans_bac
IPR027417 P-loop_NTPase
IPR004614 P_AcTrfase
IPR002505 PTA_PTB
IPR028979 Ser_kin/Pase_Hpr-like_N_sf
PfamiView protein in Pfam
PF07085 DRTGG, 1 hit
PF01515 PTA_PTB, 1 hit
PIRSFiPIRSF006107 PhpActrans_proteobac, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF75138 SSF75138, 1 hit
TIGRFAMsiTIGR00651 pta, 1 hit

Sequencei

Sequence statusi: Complete.

Q6FEP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTILMIPTG EGVGLTSACL GLIYALDCNG IKAGFLKPFS QELPNQVDRT
60 70 80 90 100
TSLFSHLFQG KTVTSISHEK VLQRLALGER DELLEEAVSI HRNVAANYDV
110 120 130 140 150
IIVEGLLPNA QDHFATELNA ALAQALDAKV VLVSTADVQN PRRTAEKIEA
160 170 180 190 200
HLHHFGGVSS NRTAGVLFMR TRGLPEETAQ IPLTIDPSLR LNTEIAAFSQ
210 220 230 240 250
ELQRYNRNLG TTTLPIIGLV PFSNTLSVPR TLDIASIIEG DWIHQGEARH
260 270 280 290 300
RRILHSSLIA SSIEYELNKF VAGELIISAS ERTDVLLASS LATSNGIPLA
310 320 330 340 350
GLVLTERKAP NPQILDFCQH AIKQGLPILH TQLNTLETAQ RLADFGNEIP
360 370 380 390 400
VDDTERAEQV TRFVSSHIDT AWLNSQINTG VQPRLSPSAF RHELVQKSIA
410 420 430 440 450
AKKRIVLPEG DEPRTVQAAA ICQSRGIAHC ILLAKPEAVV EVAKARGIEL
460 470 480 490 500
PDDLEIIDPD LIRNQYITPM VELRNGKLNE LQAKEQLQDT VVLGTMMLAL
510 520 530 540 550
DQVDGLVSGA IHTTANTVRP AFQLIKTAPD YSLVSSVFFM LLPDEVYVYG
560 570 580 590 600
DCAINPDPDA DQLAEIAIQS ADSAKAFGIN PRIAMISYST GTSGAGADVE
610 620 630 640 650
KVAKATEIAK QRRPDLLIDG PLQYDAASVE SVGRQKAPDS QVAGRANVFI
660 670 680 690 700
FPDLNTGNTT YKAVQRSANV VSVGPMLQGL NKPVNDLSRG ALVDDIVFTI
710 720
ALTAIQAEQQ LEAKAAALAS
Length:720
Mass (Da):77,882
Last modified:July 19, 2004 - v1
Checksum:i2657B1A8C48606CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR543861 Genomic DNA Translation: CAG67466.1
RefSeqiWP_004920051.1, NC_005966.1

Genome annotation databases

EnsemblBacteriaiCAG67466; CAG67466; ACIAD0540
KEGGiaci:ACIAD0540

Similar proteinsi

Entry informationi

Entry nameiPTA_ACIAD
AccessioniPrimary (citable) accession number: Q6FEP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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