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Q6FEC8

- HISX_ACIAD

UniProt

Q6FEC8 - HISX_ACIAD

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Protein
Histidinol dehydrogenase
Gene
hisD, ACIAD0663
Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei131 – 1311NAD By similarity
Binding sitei192 – 1921NAD By similarity
Binding sitei215 – 2151NAD By similarity
Binding sitei238 – 2381Substrate By similarity
Metal bindingi260 – 2601Zinc By similarity
Binding sitei260 – 2601Substrate By similarity
Metal bindingi263 – 2631Zinc By similarity
Binding sitei263 – 2631Substrate By similarity
Active sitei328 – 3281Proton acceptor By similarity
Active sitei329 – 3291Proton acceptor By similarity
Binding sitei329 – 3291Substrate By similarity
Metal bindingi362 – 3621Zinc By similarity
Binding sitei362 – 3621Substrate By similarity
Binding sitei416 – 4161Substrate By similarity
Metal bindingi421 – 4211Zinc By similarity
Binding sitei421 – 4211Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciASP62977:GJVV-626-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:ACIAD0663
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
ProteomesiUP000000430: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Histidinol dehydrogenaseUniRule annotation
PRO_0000135713Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62977.ACIAD0663.

Structurei

3D structure databases

ProteinModelPortaliQ6FEC8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FEC8-1 [UniParc]FASTAAdd to Basket

« Hide

MMRRLSTQDQ SFKQVFADLL AFETVNDPEL LKTVDQIIAD VRQYGDEHVL    50
KLTQQFDRHP AHQFSDLELT QEQLKTAFEA LTAEIREALE LAAERIRSFH 100
QAQKQEGWSY VDALGNTLGQ KVTPLDRVGI YVPGGLASYP SSVLMNAIPA 150
HVAGVPEIIM VVPAPNGELN SLVLAAAYLA GVSRIFTIGG AQAVAALAYG 200
TQTIPAVDKI TGPGNRFVAA AKRAVFGQVG IDMIAGPSEI LVYAEGQNNA 250
KWLAMDLLSQ AEHDTVAQAI FITPDEALLD EVAQAIEEHL AALPKADIAR 300
TSIANRGALV LVKDRDEAIE LINQVAPEHL ELCLDESEAM SQKIRHAGAI 350
FMGRYTPEAI GDYCAGPNHV LPTSGTARFS SPLGVYDFQK RSSLIMCSQE 400
GVKSLAKAAD VLAQQENLDA HARSARYRYQ 430
Length:430
Mass (Da):46,671
Last modified:July 19, 2004 - v1
Checksum:i75B7CFF03AB94510
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR543861 Genomic DNA. Translation: CAG67580.1.
RefSeqiWP_011182111.1. NC_005966.1.
YP_045402.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG67580; CAG67580; ACIAD0663.
GeneIDi2878926.
KEGGiaci:ACIAD0663.
PATRICi20739230. VBIAciSp98416_0585.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR543861 Genomic DNA. Translation: CAG67580.1 .
RefSeqi WP_011182111.1. NC_005966.1.
YP_045402.1. NC_005966.1.

3D structure databases

ProteinModelPortali Q6FEC8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62977.ACIAD0663.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG67580 ; CAG67580 ; ACIAD0663 .
GeneIDi 2878926.
KEGGi aci:ACIAD0663.
PATRICi 20739230. VBIAciSp98416_0585.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci ASP62977:GJVV-626-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
    Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
    Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33305 / BD413 / ADP1.

Entry informationi

Entry nameiHISX_ACIAD
AccessioniPrimary (citable) accession number: Q6FEC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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