Histidinol dehydrogenase - Acinetobacter sp. (strain ADP1)

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Reviewed, UniProtKB/Swiss-Prot Q6FEC8 (HISX_ACIAD)

Last modified November 25, 2008. Version 34. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Histidinol dehydrogenase
      Short name=HDH
    EC=1.1.1.23

Gene names

Name:	hisD
Ordered Locus Names:	ACIAD0663

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.
Catalytic activity	L-histidinol + 2 NAD(+) = L-histidine + 2 NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Sequence similarities	Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

430

Histidinol dehydrogenase

PRO_0000135713

Sites

Active site

1

Proton acceptor By similarity

Active site

1

Proton acceptor By similarity

Metal binding

1

Zinc By similarity

Metal binding

1

Zinc By similarity

Metal binding

1

Zinc By similarity

Metal binding

1

Zinc By similarity

Binding site

1

NAD By similarity

Binding site

1

NAD By similarity

Binding site

1

NAD By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q6FEC8-1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 75B7CFF03AB94510
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430

46,671

        10         20         30         40         50         60 
MMRRLSTQDQ SFKQVFADLL AFETVNDPEL LKTVDQIIAD VRQYGDEHVL KLTQQFDRHP 

        70         80         90        100        110        120 
AHQFSDLELT QEQLKTAFEA LTAEIREALE LAAERIRSFH QAQKQEGWSY VDALGNTLGQ 

       130        140        150        160        170        180 
KVTPLDRVGI YVPGGLASYP SSVLMNAIPA HVAGVPEIIM VVPAPNGELN SLVLAAAYLA 

       190        200        210        220        230        240 
GVSRIFTIGG AQAVAALAYG TQTIPAVDKI TGPGNRFVAA AKRAVFGQVG IDMIAGPSEI 

       250        260        270        280        290        300 
LVYAEGQNNA KWLAMDLLSQ AEHDTVAQAI FITPDEALLD EVAQAIEEHL AALPKADIAR 

       310        320        330        340        350        360 
TSIANRGALV LVKDRDEAIE LINQVAPEHL ELCLDESEAM SQKIRHAGAI FMGRYTPEAI 

       370        380        390        400        410        420 
GDYCAGPNHV LPTSGTARFS SPLGVYDFQK RSSLIMCSQE GVKSLAKAAD VLAQQENLDA 

       430 
HARSARYRYQ

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
	CR543861 Genomic DNA. Translation: CAG67580.1.
RefSeq	YP_045402.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2878926.
GenomeReviews	Gene locus ACIAD0663 in contig CR543861_GR.
KEGG	aci:ACIAD0663.
NMPDR	fig\|62977.3.peg.361.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6FEC8.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD0663-MON.
Family and domain databases
HAMAP	MF_01024. [Tree]
InterPro	IPR001692. Histidinol_DHase. IPR012131. Hstdl_DHase_prok. [Graphical view]
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PRINTS	PR00083. HOLDHDRGNASE.
ProDom	PD002680. Histidinol_dh. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00069. hisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX_ACIAD

Accession

Primary (citable) accession number: Q6FEC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	July 19, 2004
Last modified:	November 25, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents