Q6FEC7 (HIS8_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	ACIAD0664

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_0000153291
Amino acid modifications
	Modified residue	219	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FEC7 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 78BB0E03684D0822	FASTA	361	40,590
	10 20 30 40 50 60 MNVTNEKMRF WSPEVRELEP YVPGEQPKIQ NLLKLNTNEN PYPPSPKVKA AVETVLVDQA 70 80 90 100 110 120 DALRLYPDPD ASLLKQAIAK QQHLSVEQVF VGNGSDEVLA HIFKAFFIQD EPILYPDISY 130 140 150 160 170 180 SFYPVYSQFF GVQTKQIPLN DHFEIVVEDY QQNNGGIIIA NPNAPTSIAL SLKNIEQILK 190 200 210 220 230 240 NNPDRVVVID EAYVDFGAES AASLVNQYDN LVVCQTTSKS RSLAGLRVGY ALAQAHLIAA 250 260 270 280 290 300 LEAVKNSFNS YPIDRFAIAA AVASFEDQAY FEEQCLKVIQ SREQLIEQLE TIGFDVLPSK 310 320 330 340 350 360 ANFIFVTHPA HVAIELAKAL REQGIIVRHF NKPRINQYLR ITVGTDEQNQ RLVNTLKLFI N

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ADP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG67581.1.
RefSeq	YP_045403.1. NC_005966.1.
3D structure databases
ProteinModelPortal	Q6FEC7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FEC7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2878925.
GenomeReviews	Gene locus ACIAD0664 in contig CR543861_GR.
KEGG	aci:ACIAD0664.
NMPDR	fig|62977.3.peg.362.
PATRIC	20739232. VBIAciSp98416_0586.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0079.
HOGENOM	HBG646350.
OMA	MKNSFNS.
PhylomeDB	Q6FEC7.
ProtClustDB	PRK05387.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD0664-MONOMER.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_ACIAD

Accession

Primary (citable) accession number: Q6FEC7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program