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Q6FEB4 (UPPP1_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 1

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1
Gene names
Name:uppP1
Ordered Locus Names:ACIAD0678
OrganismAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) [Complete proteome] [HAMAP]
Taxonomic identifier62977 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Undecaprenyl-diphosphatase 1 HAMAP-Rule MF_01006
PRO_0000151076

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane146 – 16621Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane217 – 23721Helical; Potential
Transmembrane249 – 26921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q6FEB4 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 17C6389EFCDCF9CD

FASTA27429,698
        10         20         30         40         50         60 
MDLLLLLKAA IMGIVEGITE FLPISSTGHL ILASELMNFW TKEKSAVFVV AIQMGAIAAV 

        70         80         90        100        110        120 
IYEYWSRLWG AATGMVTGEE KGRHLAISLI LASIPIVLVG LSFGQTVKDL LFNDVAVAIG 

       130        140        150        160        170        180 
LIVGGVIIMW IEKNPPKVNA VEVENIGLKQ AIWIGLIQVL SLIPGTSRSG ATIIGAMFLG 

       190        200        210        220        230        240 
VSRKAATEFS FFLGIPVIIG AGLLDLYQSH EVLQTSFDWS VLGVGILVSF VSALLLIRAL 

       250        260        270 
VAYVAKRDFM VFAWYRIVSG LLILLFAYTG WTIW 

« Hide

References

[1]"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33305 / BD413 / ADP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR543861 Genomic DNA. Translation: CAG67594.1.
RefSeqYP_045416.1. NC_005966.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING62977.ACIAD0678.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG67594; CAG67594; ACIAD0678.
GeneID2881078.
KEGGaci:ACIAD0678.
PATRIC20739256. VBIAciSp98416_0598.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAWDKIMST.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycASP62977:GJVV-639-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP1_ACIAD
AccessionPrimary (citable) accession number: Q6FEB4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families