Q6FDQ8 (ARGB_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	ACIAD0903

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000112572
Regions
	Region	67 – 68	2	Substrate binding By similarity
Sites
	Binding site	89	1	Substrate By similarity
	Binding site	193	1	Substrate By similarity
	Site	32	1	Transition state stabilizer By similarity
	Site	253	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FDQ8 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 561AAE060FE61AB5	FASTA	303	32,305
	10 20 30 40 50 60 MPHQHKGIDK AKILTEALPY IQRFSGKTLV VKYGGNAMTD PELESSFARD IVLLKTVGLN 70 80 90 100 110 120 PIVVHGGGPQ VDSLLKRLGQ VSDRIDGMRV TDEATMEVVE MVLGGSVNKS IVNLINQHGG 130 140 150 160 170 180 RAIGLTGKDG NLIRARKLLM EKHDEQGDIK HIDLGLVGEV VGIKTDVLEM FTQSDFIPVI 190 200 210 220 230 240 APLGVDESGN TYNINADLVA GKVAEALGAE KLILLTNISG VLDENKNLLT GLSTQEVDRL 250 260 270 280 290 300 IATGVIYGGM IPKVGCALDA VKGGVVSAHI VDGRVPHATL LEIFTDHGVG TLITNRLHAK SEH

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ADP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG67800.1.
RefSeq	YP_045622.1. NC_005966.1.
3D structure databases
ProteinModelPortal	Q6FDQ8.
SMR	Q6FDQ8. Positions 11-296.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FDQ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2877974.
GenomeReviews	Gene locus ACIAD0903 in contig CR543861_GR.
KEGG	aci:ACIAD0903.
NMPDR	fig|62977.3.peg.904.
PATRIC	20739692. VBIAciSp98416_0810.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	GGNAMID.
PhylomeDB	Q6FDQ8.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD0903-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_ACIAD

Accession

Primary (citable) accession number: Q6FDQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program