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Q6FDP8 (UPPP2_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 2

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene names
Name:uppP2
Ordered Locus Names:ACIAD0914
OrganismAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) [Complete proteome] [HAMAP]
Taxonomic identifier62977 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Undecaprenyl-diphosphatase 2 HAMAP-Rule MF_01006
PRO_0000151077

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane47 – 6721Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane198 – 21821Helical; Potential
Transmembrane235 – 25521Helical; Potential
Transmembrane265 – 28521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q6FDP8 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 8A99AC668C1B11A3

FASTA28531,186
        10         20         30         40         50         60 
MSHAMDLLHV FILAVIQGLA ELLPVSSSAH VILAEKLMGF DPSAPNMTFL LVMLHTGTMF 

        70         80         90        100        110        120 
AVIVYFWHSW KKTYFFDWQS FKQRAWYVLL ATAITGVLGL LLQSLIKHVF FGGVSSFEIE 

       130        140        150        160        170        180 
HLFSNSKLMA AALAAAGILI ILSSRLDRGQ QGDIRLPSAM IIGAVQALCL PFRGFSRSGA 

       190        200        210        220        230        240 
TISTGLFLGI SRQKAEEFSF ALAVVLTPAV IVKELVRLLH AQHATTGATH LALGSLLLPS 

       250        260        270        280 
IFGMVFSFLT GLLALKWLSA WLEHGRWYLF GIYCLAFSGV VLTLA 

« Hide

References

[1]"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33305 / BD413 / ADP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR543861 Genomic DNA. Translation: CAG67810.1.
RefSeqYP_045632.1. NC_005966.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING62977.ACIAD0914.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG67810; CAG67810; ACIAD0914.
GeneID2878759.
KEGGaci:ACIAD0914.
PATRIC20739712. VBIAciSp98416_0820.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMACLPFRGF.
OrthoDBEOG6PW24M.

Enzyme and pathway databases

BioCycASP62977:GJVV-861-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP2_ACIAD
AccessionPrimary (citable) accession number: Q6FDP8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families