Reviewed, UniProtKB/Swiss-Prot Q6FDP8 (UPPP2_ACIAD)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2

Gene names

Name:	uppP2
Ordered Locus Names:	ACIAD0914

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000151077
Regions
	Transmembrane	5 – 25	21	Potential
	Transmembrane	47 – 67	21	Potential
	Transmembrane	86 – 106	21	Potential
	Transmembrane	122 – 142	21	Potential
	Transmembrane	156 – 176	21	Potential
	Transmembrane	198 – 218	21	Potential
	Transmembrane	235 – 255	21	Potential
	Transmembrane	265 – 285	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6FDP8-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 8A99AC668C1B11A3	FASTA	285	31,186
	10 20 30 40 50 60 MSHAMDLLHV FILAVIQGLA ELLPVSSSAH VILAEKLMGF DPSAPNMTFL LVMLHTGTMF 70 80 90 100 110 120 AVIVYFWHSW KKTYFFDWQS FKQRAWYVLL ATAITGVLGL LLQSLIKHVF FGGVSSFEIE 130 140 150 160 170 180 HLFSNSKLMA AALAAAGILI ILSSRLDRGQ QGDIRLPSAM IIGAVQALCL PFRGFSRSGA 190 200 210 220 230 240 TISTGLFLGI SRQKAEEFSF ALAVVLTPAV IVKELVRLLH AQHATTGATH LALGSLLLPS 250 260 270 280 IFGMVFSFLT GLLALKWLSA WLEHGRWYLF GIYCLAFSGV VLTLA

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG67810.1.
RefSeq	YP_045632.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FDP8.
Genome annotation databases
GeneID	2878759.
GenomeReviews	Gene locus ACIAD0914 in contig CR543861_GR.
KEGG	aci:ACIAD0914.
NMPDR	fig|62977.3.peg.914.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HBG391969.
OMA	MFAVIVY.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD0914-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP2_ACIAD

Accession

Primary (citable) accession number: Q6FDP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 19, 2004
Last modified:	January 19, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)