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Q6FDP8

- UPPP2_ACIAD

UniProt

Q6FDP8 - UPPP2_ACIAD

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Protein

Undecaprenyl-diphosphatase 2

Gene
uppP2, ACIAD0914
Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciASP62977:GJVV-861-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 2 (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene namesi
Name:uppP2
Ordered Locus Names:ACIAD0914
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
ProteomesiUP000000430: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Reviewed predictionAdd
BLAST
Transmembranei47 – 6721Helical; Reviewed predictionAdd
BLAST
Transmembranei86 – 10621Helical; Reviewed predictionAdd
BLAST
Transmembranei122 – 14221Helical; Reviewed predictionAdd
BLAST
Transmembranei156 – 17621Helical; Reviewed predictionAdd
BLAST
Transmembranei198 – 21821Helical; Reviewed predictionAdd
BLAST
Transmembranei235 – 25521Helical; Reviewed predictionAdd
BLAST
Transmembranei265 – 28521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Undecaprenyl-diphosphatase 2UniRule annotationPRO_0000151077Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62977.ACIAD0914.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiCLPFRGF.
OrthoDBiEOG6PW24M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FDP8-1 [UniParc]FASTAAdd to Basket

« Hide

MSHAMDLLHV FILAVIQGLA ELLPVSSSAH VILAEKLMGF DPSAPNMTFL    50
LVMLHTGTMF AVIVYFWHSW KKTYFFDWQS FKQRAWYVLL ATAITGVLGL 100
LLQSLIKHVF FGGVSSFEIE HLFSNSKLMA AALAAAGILI ILSSRLDRGQ 150
QGDIRLPSAM IIGAVQALCL PFRGFSRSGA TISTGLFLGI SRQKAEEFSF 200
ALAVVLTPAV IVKELVRLLH AQHATTGATH LALGSLLLPS IFGMVFSFLT 250
GLLALKWLSA WLEHGRWYLF GIYCLAFSGV VLTLA 285
Length:285
Mass (Da):31,186
Last modified:July 19, 2004 - v1
Checksum:i8A99AC668C1B11A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR543861 Genomic DNA. Translation: CAG67810.1.
RefSeqiWP_011182166.1. NC_005966.1.
YP_045632.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG67810; CAG67810; ACIAD0914.
GeneIDi2878759.
KEGGiaci:ACIAD0914.
PATRICi20739712. VBIAciSp98416_0820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR543861 Genomic DNA. Translation: CAG67810.1 .
RefSeqi WP_011182166.1. NC_005966.1.
YP_045632.1. NC_005966.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62977.ACIAD0914.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG67810 ; CAG67810 ; ACIAD0914 .
GeneIDi 2878759.
KEGGi aci:ACIAD0914.
PATRICi 20739712. VBIAciSp98416_0820.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi CLPFRGF.
OrthoDBi EOG6PW24M.

Enzyme and pathway databases

BioCyci ASP62977:GJVV-861-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
    Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
    Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33305 / BD413 / ADP1.

Entry informationi

Entry nameiUPPP2_ACIAD
AccessioniPrimary (citable) accession number: Q6FDP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi