Reviewed, UniProtKB/Swiss-Prot Q6FDF9 (BETA_ACIAD)

Names and origin

Protein names

Recommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	ACIAD1008

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	553 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity.
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular alcohol metabolic process Inferred from electronic annotation. Source: InterPro glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 553	553	Choline dehydrogenase		PRO_0000258916
Regions
	Nucleotide binding	7 – 36	30	FAD Probable
Sites
	Active site	477	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FDF9-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 7598EDF99C03839C	FASTA	553	61,478
	10 20 30 40 50 60 MTTQTFDYII IGAGSAGNVL AARLTEDADV SVLLLEAGGP DYRLDFRTQM PAALAYPLQG 70 80 90 100 110 120 RRYNWAYLTE PEPHMNNRRM ECGRGKGLGG SSLINGMCYI RGNAMDLEGW SKLKGLENWT 130 140 150 160 170 180 YADCLPYYKK AETRDIGGND YHGDHGPVSV ATPKDNNNVL FHAMVEAGVQ AGYPRTDDLN 190 200 210 220 230 240 GYQQEGFGPM DRTVTKNGRR SSTARGYLDM AKERPNLTII THAMTNKILF NGKQAIGVEY 250 260 270 280 290 300 IQGADKRDLK KVMANKEVLL CAGAIASPQI LQRSGVGEST FLKSMDIDVV HDLPGVGENL 310 320 330 340 350 360 QDHLEMYLQY KCKQPVSLYP ALKWYNQPAI GAEWLFLGKG IGASNQFEAG GFIRSSDEFE 370 380 390 400 410 420 WPNIQYHFLP VAINYNGSNA VKEHGFQAHV GSMRSPSRGH IKLKSKDPFE HPSILFNYMS 430 440 450 460 470 480 TEQDWQEFRA AIRITREIMH QPALDPYRGE EISPGKQLST DTQLDDFVRN HAETAYHPSC 490 500 510 520 530 540 SCKMGEDDMA VVDHQGRVHG LQGLRVVDAS IMPLIITGNL NATTIMMAEK IADQIRERAP 550 LPRSDAPFYV ASA

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR543861 Genomic DNA. Translation: CAG67899.1.
RefSeq	YP_045721.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2880313.
GenomeReviews	Gene locus ACIAD1008 in contig CR543861_GR.
KEGG	aci:ACIAD1008.
NMPDR	fig|62977.3.peg.1059.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6FDF9.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD1008-MON.
Family and domain databases
HAMAP	MF_00750. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. betA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_ACIAD

Accession

Primary (citable) accession number: Q6FDF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 19, 2004
Last modified:	November 25, 2008
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)