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Q6FDF9

- BETA_ACIAD

UniProt

Q6FDF9 - BETA_ACIAD

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Protein

Oxygen-dependent choline dehydrogenase

Gene
betA, ACIAD1008
Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei477 – 4771 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 3630FAD By similarityAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciASP62977:GJVV-951-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:ACIAD1008
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
ProteomesiUP000000430: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Oxygen-dependent choline dehydrogenaseUniRule annotationPRO_0000258916Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62977.ACIAD1008.

Structurei

3D structure databases

ProteinModelPortaliQ6FDF9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FDF9-1 [UniParc]FASTAAdd to Basket

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MTTQTFDYII IGAGSAGNVL AARLTEDADV SVLLLEAGGP DYRLDFRTQM    50
PAALAYPLQG RRYNWAYLTE PEPHMNNRRM ECGRGKGLGG SSLINGMCYI 100
RGNAMDLEGW SKLKGLENWT YADCLPYYKK AETRDIGGND YHGDHGPVSV 150
ATPKDNNNVL FHAMVEAGVQ AGYPRTDDLN GYQQEGFGPM DRTVTKNGRR 200
SSTARGYLDM AKERPNLTII THAMTNKILF NGKQAIGVEY IQGADKRDLK 250
KVMANKEVLL CAGAIASPQI LQRSGVGEST FLKSMDIDVV HDLPGVGENL 300
QDHLEMYLQY KCKQPVSLYP ALKWYNQPAI GAEWLFLGKG IGASNQFEAG 350
GFIRSSDEFE WPNIQYHFLP VAINYNGSNA VKEHGFQAHV GSMRSPSRGH 400
IKLKSKDPFE HPSILFNYMS TEQDWQEFRA AIRITREIMH QPALDPYRGE 450
EISPGKQLST DTQLDDFVRN HAETAYHPSC SCKMGEDDMA VVDHQGRVHG 500
LQGLRVVDAS IMPLIITGNL NATTIMMAEK IADQIRERAP LPRSDAPFYV 550
ASA 553
Length:553
Mass (Da):61,478
Last modified:July 19, 2004 - v1
Checksum:i7598EDF99C03839C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR543861 Genomic DNA. Translation: CAG67899.1.
RefSeqiYP_045721.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG67899; CAG67899; ACIAD1008.
GeneIDi2880313.
KEGGiaci:ACIAD1008.
PATRICi20739874. VBIAciSp98416_0901.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR543861 Genomic DNA. Translation: CAG67899.1 .
RefSeqi YP_045721.1. NC_005966.1.

3D structure databases

ProteinModelPortali Q6FDF9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62977.ACIAD1008.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG67899 ; CAG67899 ; ACIAD1008 .
GeneIDi 2880313.
KEGGi aci:ACIAD1008.
PATRICi 20739874. VBIAciSp98416_0901.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci ASP62977:GJVV-951-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
    Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
    Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33305 / BD413 / ADP1.

Entry informationi

Entry nameiBETA_ACIAD
AccessioniPrimary (citable) accession number: Q6FDF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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