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Q6FDF9 (BETA_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:ACIAD1008
OrganismAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) [Complete proteome] [HAMAP]
Taxonomic identifier62977 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_0000258916

Regions

Nucleotide binding7 – 3630FAD By similarity

Sites

Active site4771 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FDF9 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 7598EDF99C03839C

FASTA55361,478
        10         20         30         40         50         60 
MTTQTFDYII IGAGSAGNVL AARLTEDADV SVLLLEAGGP DYRLDFRTQM PAALAYPLQG 

        70         80         90        100        110        120 
RRYNWAYLTE PEPHMNNRRM ECGRGKGLGG SSLINGMCYI RGNAMDLEGW SKLKGLENWT 

       130        140        150        160        170        180 
YADCLPYYKK AETRDIGGND YHGDHGPVSV ATPKDNNNVL FHAMVEAGVQ AGYPRTDDLN 

       190        200        210        220        230        240 
GYQQEGFGPM DRTVTKNGRR SSTARGYLDM AKERPNLTII THAMTNKILF NGKQAIGVEY 

       250        260        270        280        290        300 
IQGADKRDLK KVMANKEVLL CAGAIASPQI LQRSGVGEST FLKSMDIDVV HDLPGVGENL 

       310        320        330        340        350        360 
QDHLEMYLQY KCKQPVSLYP ALKWYNQPAI GAEWLFLGKG IGASNQFEAG GFIRSSDEFE 

       370        380        390        400        410        420 
WPNIQYHFLP VAINYNGSNA VKEHGFQAHV GSMRSPSRGH IKLKSKDPFE HPSILFNYMS 

       430        440        450        460        470        480 
TEQDWQEFRA AIRITREIMH QPALDPYRGE EISPGKQLST DTQLDDFVRN HAETAYHPSC 

       490        500        510        520        530        540 
SCKMGEDDMA VVDHQGRVHG LQGLRVVDAS IMPLIITGNL NATTIMMAEK IADQIRERAP 

       550 
LPRSDAPFYV ASA 

« Hide

References

[1]"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33305 / BD413 / ADP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR543861 Genomic DNA. Translation: CAG67899.1.
RefSeqYP_045721.1. NC_005966.1.

3D structure databases

ProteinModelPortalQ6FDF9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING62977.ACIAD1008.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG67899; CAG67899; ACIAD1008.
GeneID2880313.
KEGGaci:ACIAD1008.
PATRIC20739874. VBIAciSp98416_0901.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMAYLQYACT.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycASP62977:GJVV-951-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_ACIAD
AccessionPrimary (citable) accession number: Q6FDF9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways