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Q6FDF8 (BETB_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:ACIAD1009
OrganismAcinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]
Taxonomic identifier62977 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processbetaine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Betaine aldehyde dehydrogenase HAMAP MF_00804
PRO_0000056534

Regions

Nucleotide binding229 – 2346NAD By similarity

Sites

Active site2521 By similarity
Active site2861 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FDF8 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 12CE36D2F4AC2D6A

FASTA49053,041
        10         20         30         40         50         60 
MSDVKLHRLY IHGQYTDATS GKTFDSINPA TGEVIATIQQ ASQTDIEAAV KSAAEGQKVW 

        70         80         90        100        110        120 
AAKTAVERSR ILRRAVDILR ERNDELAQLE TLDTGKAFSE TSTVDIVTGA DVLEYYAGLA 

       130        140        150        160        170        180 
TAIQGEQVPL RESSFFYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 

       190        200        210        220        230        240 
TPLTAFKLAE IYSEAGLPAG VFNVVQGAGR EIGQWLTEHA VIEKISFTGG VETGKKVMAS 

       250        260        270        280        290        300 
AAGSTLKEVT MELGGKSPLI ICEDANLDRA ADIAVMANFF SSGQVCTNGT RVFIPQRLKA 

       310        320        330        340        350        360 
AFEQAVVERV KRIRMGDPQH TDTNFGPLVS FPHMEKVLSY IESGKQQGAK VLIGGERATT 

       370        380        390        400        410        420 
GLLAQGAYVQ PTVFTDCHDD MKIVQEEIFG PVMSILTYDT IEEAIERANN TNFGLAAGVV 

       430        440        450        460        470        480 
TQNISQAHQI IHQLEAGICW INTWGESPAE MPVGGYKESG VGRENGISTL NHYTRTKSIQ 

       490 
VELGDYQSVF

« Hide

References

[1]"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ADP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR543861 Genomic DNA. Translation: CAG67900.1.
RefSeqYP_045722.1. NC_005966.1.

3D structure databases

ProteinModelPortalQ6FDF8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6FDF8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2880314.
GenomeReviewsGene locus ACIAD1009 in contig CR543861_GR.
KEGGaci:ACIAD1009.
NMPDRfig|62977.3.peg.1060.
PATRIC20739876. VBIAciSp98416_0902.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHBG752218.
OMAGRENGLM.
PhylomeDBQ6FDF8.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycASP62977:ACIAD1009-MONOMER.

Family and domain databases

HAMAPMF_00804. BADH.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00130.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_ACIAD
AccessionPrimary (citable) accession number: Q6FDF8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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