Reviewed, UniProtKB/Swiss-Prot Q6FDF8 (BETB_ACIAD)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	ACIAD1009

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_0000056534
Regions
	Nucleotide binding	229 – 234	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FDF8-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 12CE36D2F4AC2D6A	FASTA	490	53,041
	10 20 30 40 50 60 MSDVKLHRLY IHGQYTDATS GKTFDSINPA TGEVIATIQQ ASQTDIEAAV KSAAEGQKVW 70 80 90 100 110 120 AAKTAVERSR ILRRAVDILR ERNDELAQLE TLDTGKAFSE TSTVDIVTGA DVLEYYAGLA 130 140 150 160 170 180 TAIQGEQVPL RESSFFYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 190 200 210 220 230 240 TPLTAFKLAE IYSEAGLPAG VFNVVQGAGR EIGQWLTEHA VIEKISFTGG VETGKKVMAS 250 260 270 280 290 300 AAGSTLKEVT MELGGKSPLI ICEDANLDRA ADIAVMANFF SSGQVCTNGT RVFIPQRLKA 310 320 330 340 350 360 AFEQAVVERV KRIRMGDPQH TDTNFGPLVS FPHMEKVLSY IESGKQQGAK VLIGGERATT 370 380 390 400 410 420 GLLAQGAYVQ PTVFTDCHDD MKIVQEEIFG PVMSILTYDT IEEAIERANN TNFGLAAGVV 430 440 450 460 470 480 TQNISQAHQI IHQLEAGICW INTWGESPAE MPVGGYKESG VGRENGISTL NHYTRTKSIQ 490 VELGDYQSVF

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR543861 Genomic DNA. Translation: CAG67900.1.
RefSeq	YP_045722.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FDF8.
Genome annotation databases
GeneID	2880314.
GenomeReviews	Gene locus ACIAD1009 in contig CR543861_GR.
KEGG	aci:ACIAD1009.
NMPDR	fig|62977.3.peg.1060.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6FDF8.
OMA	TLKEVTM.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD1009-MON.
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_ACIAD

Accession

Primary (citable) accession number: Q6FDF8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)