Reviewed, UniProtKB/Swiss-Prot Q6FCU0 (ADD_ACIAD)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	ACIAD1245

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Adenosine deaminase HAMAP MF_00540		PRO_1000128834
Sites
	Active site	196	1	Potential
	Active site	244	1	Potential
	Active site	277	1	Potential
	Active site	278	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6FCU0-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 496FCC96BA68724A	FASTA	332	38,108
	10 20 30 40 50 60 MNQSELIRAL PKAELHVHIE GTFEPELMFE IAQRNHIDIP YKSVEEIKKA YNFHNLQSFL 70 80 90 100 110 120 DIYYAGANVL INEQDFYDLA WAYFKKCAED RVVHTEMFFD PQTHTERGVS FEIVLNGLKR 130 140 150 160 170 180 ACKDAKEHLG ISSHLIMCFL RHLSEEDAFK TLEQALPYKA DIIAVGLDSS EVGHPPSKFA 190 200 210 220 230 240 RVFEKAREEG FLVVAHAGEE GPPEYVWEAL DLLKVNRIDH GVRSEEDPAL MQRLIQEKMP 250 260 270 280 290 300 LTVCPLSNLK LCVVNDMKEH NIRRLLNQGV HVTVNSDDPS YFGGYMNDNF VAIQAALDLS 310 320 330 NEELKKLAIN SFEASFIDEE EKQNWIEEIN QI

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR543861 Genomic DNA. Translation: CAG68119.1.
RefSeq	YP_045941.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FCU0.
Genome annotation databases
GeneID	2879613.
GenomeReviews	Gene locus ACIAD1245 in contig CR543861_GR.
KEGG	aci:ACIAD1245.
NMPDR	fig|62977.3.peg.314.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6FCU0.
OMA	LAQNSLD.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD1245-MON.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_ACIAD

Accession

Primary (citable) accession number: Q6FCU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)