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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. aspartate carbamoyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  3. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciASP62977:GJVV-1201-MONOMER.
UniPathwayiUPA00070; UER00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:ACIAD1270
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
ProteomesiUP000000430 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Aspartate carbamoyltransferasePRO_0000113083Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62977.ACIAD1270.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0540.
HOGENOMiHOG000022685.
KOiK00609.
OMAiHEHPSQG.
OrthoDBiEOG61KBJZ.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FCR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLAALHTPS QIQLNQQGNL KHFLTIEGLS KETLTKILDT AQSFINDQNQ
60 70 80 90 100
LITTPLLEGR TVMNLFFENS TRTRTTFEAA AKRLSANVLN IDIARSSTSK
110 120 130 140 150
GETLRDTLWN LEAMAADIFV VRHSSSGAAH FIAKDVCPHV AIINAGDGRH
160 170 180 190 200
AHPTQAMLDM LTIRRETKKP FEELSVAIIG DIKHSRVARS NIAALQTLGC
210 220 230 240 250
NDIRVIAPNT LLPVGFKEYG DHVRLFNKMD DGVKDCDVII ALRIQNERID
260 270 280 290 300
SPALSSQAEF YRMYGLNQER LALAKPDCIV MHPGPMNRGV EIDSSIADGP
310 320 330
QSVILHQVTN GIAVRMAVLA LSMQGQLQEQ GLIEAIAV
Length:338
Mass (Da):37,189
Last modified:July 18, 2004 - v1
Checksum:i3FE954721427F7BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR543861 Genomic DNA. Translation: CAG68144.1.
RefSeqiYP_045966.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG68144; CAG68144; ACIAD1270.
KEGGiaci:ACIAD1270.
PATRICi20740365. VBIAciSp98416_1141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR543861 Genomic DNA. Translation: CAG68144.1.
RefSeqiYP_045966.1. NC_005966.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi62977.ACIAD1270.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG68144; CAG68144; ACIAD1270.
KEGGiaci:ACIAD1270.
PATRICi20740365. VBIAciSp98416_1141.

Phylogenomic databases

eggNOGiCOG0540.
HOGENOMiHOG000022685.
KOiK00609.
OMAiHEHPSQG.
OrthoDBiEOG61KBJZ.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00116.
BioCyciASP62977:GJVV-1201-MONOMER.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
    Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
    Nucleic Acids Res. 32:5766-5779(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33305 / BD413 / ADP1.

Entry informationi

Entry nameiPYRB_ACIAD
AccessioniPrimary (citable) accession number: Q6FCR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 14, 2005
Last sequence update: July 18, 2004
Last modified: March 31, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.