Q6FCR5 (PYRB_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	ACIAD1270

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP-Rule MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP-Rule MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' UMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway 'de novo' pyrimidine nucleobase biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Aspartate carbamoyltransferase HAMAP-Rule MF_00001		PRO_0000113083

Sequences

	Sequence		Length	Mass (Da)
	Q6FCR5 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 3FE954721427F7BC	FASTA	338	37,189
	10 20 30 40 50 60 MHLAALHTPS QIQLNQQGNL KHFLTIEGLS KETLTKILDT AQSFINDQNQ LITTPLLEGR 70 80 90 100 110 120 TVMNLFFENS TRTRTTFEAA AKRLSANVLN IDIARSSTSK GETLRDTLWN LEAMAADIFV 130 140 150 160 170 180 VRHSSSGAAH FIAKDVCPHV AIINAGDGRH AHPTQAMLDM LTIRRETKKP FEELSVAIIG 190 200 210 220 230 240 DIKHSRVARS NIAALQTLGC NDIRVIAPNT LLPVGFKEYG DHVRLFNKMD DGVKDCDVII 250 260 270 280 290 300 ALRIQNERID SPALSSQAEF YRMYGLNQER LALAKPDCIV MHPGPMNRGV EIDSSIADGP 310 320 330 QSVILHQVTN GIAVRMAVLA LSMQGQLQEQ GLIEAIAV

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ADP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG68144.1.
RefSeq	YP_045966.1. NC_005966.1.
3D structure databases
ProteinModelPortal	Q6FCR5.
ModBase	Search...
Protein-protein interaction databases
STRING	62977.ACIAD1270.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAG68144; CAG68144; ACIAD1270.
GeneID	2879563.
KEGG	aci:ACIAD1270.
PATRIC	20740365. VBIAciSp98416_1141.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HOG000022685.
KO	K00609.
OMA	LTIRQHK.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	ASP62977:GJVV-1201-MONOMER.
UniPathway	UPA00070; UER00116.
Family and domain databases
Gene3D	3.40.50.1370. 2 hits.
HAMAP	MF_00001. Asp_carb_tr.
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR002082. Asp_carbamoyltransf. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_ACIAD

Accession

Primary (citable) accession number: Q6FCR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	July 19, 2004
Last modified:	May 29, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program