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Q6FCR5 (PYRB_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aspartate carbamoyltransferase

EC=2.1.3.2
Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase
Gene names
Name:pyrB
Ordered Locus Names:ACIAD1270
OrganismAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) [Complete proteome] [HAMAP]
Taxonomic identifier62977 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP-Rule MF_00001

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP-Rule MF_00001

Sequence similarities

Belongs to the ATCase/OTCase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Aspartate carbamoyltransferase HAMAP-Rule MF_00001
PRO_0000113083

Sequences

Sequence LengthMass (Da)Tools
Q6FCR5 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 3FE954721427F7BC

FASTA33837,189
        10         20         30         40         50         60 
MHLAALHTPS QIQLNQQGNL KHFLTIEGLS KETLTKILDT AQSFINDQNQ LITTPLLEGR 

        70         80         90        100        110        120 
TVMNLFFENS TRTRTTFEAA AKRLSANVLN IDIARSSTSK GETLRDTLWN LEAMAADIFV 

       130        140        150        160        170        180 
VRHSSSGAAH FIAKDVCPHV AIINAGDGRH AHPTQAMLDM LTIRRETKKP FEELSVAIIG 

       190        200        210        220        230        240 
DIKHSRVARS NIAALQTLGC NDIRVIAPNT LLPVGFKEYG DHVRLFNKMD DGVKDCDVII 

       250        260        270        280        290        300 
ALRIQNERID SPALSSQAEF YRMYGLNQER LALAKPDCIV MHPGPMNRGV EIDSSIADGP 

       310        320        330 
QSVILHQVTN GIAVRMAVLA LSMQGQLQEQ GLIEAIAV 

« Hide

References

[1]"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33305 / BD413 / ADP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR543861 Genomic DNA. Translation: CAG68144.1.
RefSeqYP_045966.1. NC_005966.1.

3D structure databases

ProteinModelPortalQ6FCR5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING62977.ACIAD1270.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG68144; CAG68144; ACIAD1270.
GeneID2879563.
KEGGaci:ACIAD1270.
PATRIC20740365. VBIAciSp98416_1141.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0540.
HOGENOMHOG000022685.
KOK00609.
OMAVMTLRLQ.
OrthoDBEOG61KBJZ.
ProtClustDBPRK00856.

Enzyme and pathway databases

BioCycASP62977:GJVV-1201-MONOMER.
UniPathwayUPA00070; UER00116.

Family and domain databases

Gene3D3.40.50.1370. 2 hits.
HAMAPMF_00001. Asp_carb_tr.
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMSSF53671. SSF53671. 1 hit.
TIGRFAMsTIGR00670. asp_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRB_ACIAD
AccessionPrimary (citable) accession number: Q6FCR5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 19, 2004
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways