ID   ASTD_ACIAD              Reviewed;         489 AA.
AC   Q6FCQ0;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   16-JUN-2009, entry version 38.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase;
DE            EC=1.2.1.71;
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase;
DE            Short=SGSD;
GN   Name=astD; OrderedLocusNames=ACIAD1287;
OS   Acinetobacter sp. (strain ADP1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Moraxellaceae; Acinetobacter.
OX   NCBI_TaxID=62977;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15514110; DOI=10.1093/nar/gkh910;
RA   Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S.,
RA   Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P.,
RA   Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.;
RT   "Unique features revealed by the genome sequence of Acinetobacter sp.
RT   ADP1, a versatile and naturally transformation competent bacterium.";
RL   Nucleic Acids Res. 32:5766-5779(2004).
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of
CC       succinylglutamate semialdehyde into succinylglutamate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
CC       + H(2)O = N-succinyl-L-glutamate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily.
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DR   EMBL; CR543861; CAG68159.1; -; Genomic_DNA.
DR   RefSeq; YP_045981.1; -.
DR   GeneID; 2880680; -.
DR   GenomeReviews; CR543861_GR; ACIAD1287.
DR   KEGG; aci:ACIAD1287; -.
DR   NMPDR; fig|62977.3.peg.410; -.
DR   HOGENOM; Q6FCQ0; -.
DR   OMA; Q6FCQ0; EMTQPQA.
DR   BioCyc; ASP62977:ACIAD1287-MON; -.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenas...; IEA:EC.
DR   GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01174; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR03240; arg_catab_astD; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    489       N-succinylglutamate 5-semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_0000262386.
FT   NP_BIND     223    228       NAD (By similarity).
FT   ACT_SITE    246    246       By similarity.
FT   ACT_SITE    280    280       By similarity.
SQ   SEQUENCE   489 AA;  52938 MW;  4DE2668956F4F2C1 CRC64;
     MSHANLWIDG NWVQGQGKSW NTCNPVSQQV VWQGNEATAQ QVEQACEAAR QAFPQWATTS
     LTDRIAIIER FALLLEQNKE ALAKIISQET SKPLWETLTE VQSMVAKVAI SIRAYHQRTG
     KSITEMADGA ASLRHRPHGV MAVFGPYNFP GHLPNGHIVP ALIAGNVVVF KPSELTPWTA
     EATVKLWQQA GLPNAVLNLL QGSRETGIAL AQSEHIDGVL FTGSASTGYQ LHRQLAGAPE
     KILALEMGGN NALIIEDIDD IDAVVHLAIQ SAFISAGQRC TCARRLIIKN GQAGDAFIQR
     FIEVARDLVI GDWDAEPQPF MGGVISVKAA EALLKAQQNL IDLGARSLLE MKQLRENSAL
     VSPAILDVTA VPDIPDEEYF GPLTCIYRYD DFDEALKLAN STRFGLSVGL VSPKRALFER
     MLIEARAGIV NWNKPLTGAS SAAPFGGVGA SGNHRASAFY AADYCAWPMA SLESEQLSLP
     EKLSPGIVL
//