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Reviewed, UniProtKB/Swiss-Prot Q6FCQ0 (ASTD_ACIAD)

Last modified November 25, 2008. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD
Gene names
Name: astD
Ordered Locus Names: ACIAD1287
OrganismAcinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]
Taxonomic identifier62977 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords

   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processarginine catabolic process to glutamate

Inferred from electronic annotation. Source: HAMAP

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489N-succinylglutamate 5-semialdehyde dehydrogenase
PRO_0000262386

Regions

Nucleotide binding223 – 2286NAD By similarity

Sites

Active site2461 By similarity
Active site2801 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FCQ0-1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 4DE2668956F4F2C1

FASTA48952,938
        10         20         30         40         50         60 
MSHANLWIDG NWVQGQGKSW NTCNPVSQQV VWQGNEATAQ QVEQACEAAR QAFPQWATTS 

        70         80         90        100        110        120 
LTDRIAIIER FALLLEQNKE ALAKIISQET SKPLWETLTE VQSMVAKVAI SIRAYHQRTG 

       130        140        150        160        170        180 
KSITEMADGA ASLRHRPHGV MAVFGPYNFP GHLPNGHIVP ALIAGNVVVF KPSELTPWTA 

       190        200        210        220        230        240 
EATVKLWQQA GLPNAVLNLL QGSRETGIAL AQSEHIDGVL FTGSASTGYQ LHRQLAGAPE 

       250        260        270        280        290        300 
KILALEMGGN NALIIEDIDD IDAVVHLAIQ SAFISAGQRC TCARRLIIKN GQAGDAFIQR 

       310        320        330        340        350        360 
FIEVARDLVI GDWDAEPQPF MGGVISVKAA EALLKAQQNL IDLGARSLLE MKQLRENSAL 

       370        380        390        400        410        420 
VSPAILDVTA VPDIPDEEYF GPLTCIYRYD DFDEALKLAN STRFGLSVGL VSPKRALFER 

       430        440        450        460        470        480 
MLIEARAGIV NWNKPLTGAS SAAPFGGVGA SGNHRASAFY AADYCAWPMA SLESEQLSLP 


EKLSPGIVL 

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References

[1]"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CR543861 Genomic DNA. Translation: CAG68159.1.
RefSeqYP_045981.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2880680.
GenomeReviewsGene locus ACIAD1287 in contig CR543861_GR.
KEGGaci:ACIAD1287.
NMPDRfig|62977.3.peg.410.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ6FCQ0.

Enzyme and pathway databases

BioCycASP62977:ACIAD1287-MON.

Family and domain databases

HAMAPMF_01174.
[Tree]
InterProIPR016160. Ald_DHase_CS.
IPR016162. Ald_DHase_N.
IPR015590. Aldehyde_DHase.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD_ACIAD
AccessionPrimary (citable) accession number: Q6FCQ0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 19, 2004
Last modified: November 25, 2008
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents