Q6FCQ0 (ASTD_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71

Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	ACIAD1287

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174		PRO_0000262386
Regions
	Nucleotide binding	223 – 228	6	NAD By similarity
Sites
	Active site	246	1	By similarity
	Active site	280	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FCQ0-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 4DE2668956F4F2C1	FASTA	489	52,938
	10 20 30 40 50 60 MSHANLWIDG NWVQGQGKSW NTCNPVSQQV VWQGNEATAQ QVEQACEAAR QAFPQWATTS 70 80 90 100 110 120 LTDRIAIIER FALLLEQNKE ALAKIISQET SKPLWETLTE VQSMVAKVAI SIRAYHQRTG 130 140 150 160 170 180 KSITEMADGA ASLRHRPHGV MAVFGPYNFP GHLPNGHIVP ALIAGNVVVF KPSELTPWTA 190 200 210 220 230 240 EATVKLWQQA GLPNAVLNLL QGSRETGIAL AQSEHIDGVL FTGSASTGYQ LHRQLAGAPE 250 260 270 280 290 300 KILALEMGGN NALIIEDIDD IDAVVHLAIQ SAFISAGQRC TCARRLIIKN GQAGDAFIQR 310 320 330 340 350 360 FIEVARDLVI GDWDAEPQPF MGGVISVKAA EALLKAQQNL IDLGARSLLE MKQLRENSAL 370 380 390 400 410 420 VSPAILDVTA VPDIPDEEYF GPLTCIYRYD DFDEALKLAN STRFGLSVGL VSPKRALFER 430 440 450 460 470 480 MLIEARAGIV NWNKPLTGAS SAAPFGGVGA SGNHRASAFY AADYCAWPMA SLESEQLSLP EKLSPGIVL

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG68159.1.
RefSeq	YP_045981.1.
3D structure databases
ProteinModelPortal	Q6FCQ0.
SMR	Q6FCQ0. Positions 1-433, 5-461.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FCQ0.
Genome annotation databases
GeneID	2880680.
GenomeReviews	Gene locus ACIAD1287 in contig CR543861_GR.
KEGG	aci:ACIAD1287.
NMPDR	fig|62977.3.peg.410.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HBG752218.
OMA	EMTQPQA.
PhylomeDB	Q6FCQ0.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD1287-MONOMER.
Family and domain databases
HAMAP	MF_01174. Aldedh_AstD. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR03240. arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_ACIAD

Accession

Primary (citable) accession number: Q6FCQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	July 19, 2004
Last modified:	August 10, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)