Reviewed, UniProtKB/Swiss-Prot Q6FCK9 (GCP_ACIAD)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	ACIAD1332

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303245
Sites
	Metal binding	111	1	Zinc Potential
	Metal binding	115	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6FCK9-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: E0384A9EAE3B2460	FASTA	340	36,723
	10 20 30 40 50 60 MIVLGLETSC DETGLALYDS EKGLLGQVLY SQIKLHAEYG GVVPELASRD HVRKMIPLLD 70 80 90 100 110 120 QLLNDSQVKK SQIDAVAYTR GPGLMGALMT GALFGRTLAF ALNKPAIGVH HMEGHMLAPL 130 140 150 160 170 180 LSATPPEFPF VALLVSGGHT QLMAAYGIGQ YELLGESIDD AAGEAFDKVA KMMGLPYPGG 190 200 210 220 230 240 PNIAKLALQG NPETFEFPRP MLHQGLDFSF SGLKTSVSVQ LKKLGEENRD ADIAASFQEA 250 260 270 280 290 300 IVDTLVKKSV KALKQTGLKR LVIAGGVSAN QRLRERLEHS LSKIKSQVYY AEPALCTDNG 310 320 330 340 AMIAFAGYQR LKAGQCDDLV VTTTPRWPMT ELSRPAEIIE

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR543861 Genomic DNA. Translation: CAG68201.1.
RefSeq	YP_046023.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FCK9.
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	2879625.
GenomeReviews	Gene locus ACIAD1332 in contig CR543861_GR.
KEGG	aci:ACIAD1332.
NMPDR	fig|62977.3.peg.505.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6FCK9.
OMA	CKRALKQ.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD1332-MON.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_ACIAD

Accession

Primary (citable) accession number: Q6FCK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)