Reviewed, UniProtKB/Swiss-Prot Q6FCI4 (ARGC_ACIAD)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	ACIAD1360

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112373
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FCI4-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: C1FACF2455B9ECCA	FASTA	349	38,132
	10 20 30 40 50 60 MISVGIVGGT GYTGVELLRL LLRHPQVTVR VLTSRTEAGK RVADMFPSLR GHTDLEFSDL 70 80 90 100 110 120 NEDVLKQCDV VFFATPHGVA MKYAKGLVAA GVKVIDLAAD FRLQNLEQFE KWYGLEHECP 130 140 150 160 170 180 EILKDSVYGL SELNREKIKT AKVVGNPGCY PTTVQLGLAP LLQADVALIK PENIIIDAKS 190 200 210 220 230 240 GVSGAGRKAS LGMIYSENAD NFKAYGVAGH RHHPEIVEAL EHISGQKGVF DQIIFVPHLV 250 260 270 280 290 300 PMIRGMLSTI YIDLTEEGAN SDLQSLYEIY YANEKFVDVM PANSSPETRS VRGANELRIA 310 320 330 340 LYKPQPNKLV ILSVQDNLVK GAAGQAVQNM NLMFNLDEDT GLTGIGLLP

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR543861 Genomic DNA. Translation: CAG68227.1.
RefSeq	YP_046049.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FCI4.
Genome annotation databases
GeneID	2877975.
GenomeReviews	Gene locus ACIAD1360 in contig CR543861_GR.
KEGG	aci:ACIAD1360.
NMPDR	fig|62977.3.peg.593.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6FCI4.
OMA	TAEDCTT.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD1360-MON.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_ACIAD

Accession

Primary (citable) accession number: Q6FCI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)