Reviewed, UniProtKB/Swiss-Prot Q6FCH8 (OTC_ACIAD)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	ACIAD1366

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_0000112870
Regions
	Region	53 – 57	5	Carbamoyl phosphate binding By similarity
	Region	258 – 261	4	Ornithine binding By similarity
Sites
	Binding site	104	1	Carbamoyl phosphate By similarity
	Binding site	131	1	Carbamoyl phosphate By similarity
	Site	28	1	Important for structural integrity By similarity
	Site	144	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FCH8-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: C44AF7CB25DD32E7	FASTA	306	34,468
	10 20 30 40 50 60 MALRHFLTLR DLSSLELNSI LDRASELKRQ QHANQVYQPF KGKVLGMIFE KSSTRTRISF 70 80 90 100 110 120 EAGICQFGGS AIFLSPRDTQ LGRGEPIEDS ARVISSMLDI VMIRTFGHNI VERFASFSKV 130 140 150 160 170 180 PVINGLTDDH HPCQLLADLQ TYQEHRGSIK GKTVAWIGDG NNMCNSYMEA AHMMGFKLKV 190 200 210 220 230 240 GSPKGYEPKP EFLAEFAHCV EVFNSAEDAA VNADLIVTDV WASMGQEEEQ KLREKAFLTF 250 260 270 280 290 300 QVNEALMALA HPECLFMHCL PAHRGEEISE NMLDHKNSVV WDEAENRLHA QKALMEFLLN ENAKRA

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG68233.1.
RefSeq	YP_046055.1.
3D structure databases
SMR	Q6FCH8. Positions 3-300.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FCH8.
Genome annotation databases
GeneID	2877978.
GenomeReviews	Gene locus ACIAD1366 in contig CR543861_GR.
KEGG	aci:ACIAD1366.
NMPDR	fig|62977.3.peg.599.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0078.
HOGENOM	HBG579429.
OMA	FTVAMYQ.
PhylomeDB	Q6FCH8.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD1366-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_ACIAD

Accession

Primary (citable) accession number: Q6FCH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)