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Q6FCG3 (Q6FCG3_ACIAD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP MF_00387
Short name=UDP-N-acetylglucosamine acyltransferase HAMAP MF_00387
EC=2.3.1.129 HAMAP MF_00387
Gene names
Name:lpxA HAMAP MF_00387 EMBL CAG68248.1
Ordered Locus Names:ACIAD1382
OrganismAcinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP] EMBL CAG68248.1
Taxonomic identifier62977 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00387 SAAS SAAS010137

Catalytic activity

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. HAMAP MF_00387 SAAS SAAS010137

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP MF_00387 SAAS SAAS010137

Subunit structure

Homotrimer By similarity. HAMAP MF_00387 SAAS SAAS010137

Subcellular location

Cytoplasm By similarity HAMAP MF_00387.

Sequence similarities

Belongs to the transferase hexapeptide repeat family. LpxA subfamily. HAMAP MF_00387

Sequences

Sequence LengthMass (Da)Tools
Q6FCG3 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 12CC4048852B1546

FASTA26228,542
        10         20         30         40         50         60 
MSNNDLIHST AIIDTSAVIA ADVQIGPYCV IGPNVTIGAG TKLHSHVVVG GYTRIGEHNE 

        70         80         90        100        110        120 
IFQFASVGEI CQDLKYKGEE TWLEIGDYNL IREHCSLHRG TIQDNSLTKI GSHNLLMVNT 

       130        140        150        160        170        180 
HIAHDCVIGD HNVFANNVGI AGHVHIGSHV VVGGNSGIHQ FCKIDSYSMV GGASLILKDV 

       190        200        210        220        230        240 
PAYVMVSGNP AHAFGMNVEG MRRKGWSKNV IQALREAYKL IYKSGLTTEQ SIQKIRNEIL 

       250        260 
PDIPEVQLLI DSVEQSQRGI VR

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References

[1]"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ADP1 EMBL CAG68248.1.
[2]Genoscope
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ADP1 EMBL CAG68248.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR543861 Genomic DNA. Translation: CAG68248.1.
RefSeqYP_046070.1. NC_005966.1.

3D structure databases

ProteinModelPortalQ6FCG3.
SMRQ6FCG3. Positions 2-262.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6FCG3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2879758.
GenomeReviewsGene locus ACIAD1382 in contig CR543861_GR.
KEGGaci:ACIAD1382.
NMPDRfig|62977.3.peg.684.
PATRIC20740580. VBIAciSp98416_1242.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1043.
HOGENOMHBG659295.
OMAREFCTFN.
PhylomeDBQ6FCG3.
ProtClustDBPRK05289.

Family and domain databases

HAMAPMF_00387. LpxA.
[Tree]
InterProIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR010137. Lipid_A_lpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view]
KOK00677.
PfamPF00132. Hexapep. 4 hits.
[Graphical view]
PIRSFPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMSSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMsTIGR01852. Lipid_A_lpxA. 1 hit.
PROSITEPS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ6FCG3_ACIAD
AccessionPrimary (citable) accession number: Q6FCG3
Entry history
Integrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info