Reviewed, UniProtKB/Swiss-Prot Q6FBS3 (UPPP3_ACIAD)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 3
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 3
    Bacitracin resistance protein 3

Gene names

Name:	uppP3
Ordered Locus Names:	ACIAD1642

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Undecaprenyl-diphosphatase 3 HAMAP MF_01006		PRO_0000151078
Regions
	Transmembrane	4 – 24	21	Potential
	Transmembrane	43 – 63	21	Potential
	Transmembrane	86 – 106	21	Potential
	Transmembrane	109 – 129	21	Potential
	Transmembrane	145 – 165	21	Potential
	Transmembrane	186 – 206	21	Potential
	Transmembrane	219 – 239	21	Potential
	Transmembrane	246 – 266	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6FBS3-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 34042859C40AF688	FASTA	266	29,179
	10 20 30 40 50 60 MGNIEAFKAL FLGFIEGLTE FLPISSTGHL ILFGHLIDFH SDSGRAFEVV IQLGAILAVC 70 80 90 100 110 120 WLYRKKIIDL VQGFFSGDQE ARHFTFSVLM AFFPAVIIGV LAVDFIKSVL FSPLVVAIAL 130 140 150 160 170 180 IIGGLIIFWV ESRDFKPSTT EATKITFKQA IAVGFIQCLA MIPGTSRSGA TIIGGMLSGL 190 200 210 220 230 240 SRKAATEFSF FLAMPTMLGA ATYDLLRNAD VLTSDNMLNI GLGFITAFIS ALFVVKALVR 250 260 FVEKHTLRVF AWYRIVLGII IMFVML

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR543861 Genomic DNA. Translation: CAG68488.1.
RefSeq	YP_046310.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FBS3.
Genome annotation databases
GeneID	2878064.
GenomeReviews	Gene locus ACIAD1642 in contig CR543861_GR.
KEGG	aci:ACIAD1642.
NMPDR	fig|62977.3.peg.1456.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6FBS3.
OMA	KPFAYYR.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD1642-MON.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP3_ACIAD

Accession

Primary (citable) accession number: Q6FBS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)