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Q6FBS3

- UPPP3_ACIAD

UniProt

Q6FBS3 - UPPP3_ACIAD

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Protein

Undecaprenyl-diphosphatase 3

Gene

uppP3

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciASP62977:GJVV-1553-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 3UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 3UniRule annotation
Undecaprenyl pyrophosphate phosphatase 3UniRule annotation
Gene namesi
Name:uppP3UniRule annotation
Ordered Locus Names:ACIAD1642
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
ProteomesiUP000000430: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalUniRule annotationAdd
BLAST
Transmembranei43 – 6321HelicalUniRule annotationAdd
BLAST
Transmembranei86 – 10621HelicalUniRule annotationAdd
BLAST
Transmembranei109 – 12921HelicalUniRule annotationAdd
BLAST
Transmembranei145 – 16521HelicalUniRule annotationAdd
BLAST
Transmembranei186 – 20621HelicalUniRule annotationAdd
BLAST
Transmembranei219 – 23921HelicalUniRule annotationAdd
BLAST
Transmembranei246 – 26621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Undecaprenyl-diphosphatase 3PRO_0000151078Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62977.ACIAD1642.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FBS3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNIEAFKAL FLGFIEGLTE FLPISSTGHL ILFGHLIDFH SDSGRAFEVV
60 70 80 90 100
IQLGAILAVC WLYRKKIIDL VQGFFSGDQE ARHFTFSVLM AFFPAVIIGV
110 120 130 140 150
LAVDFIKSVL FSPLVVAIAL IIGGLIIFWV ESRDFKPSTT EATKITFKQA
160 170 180 190 200
IAVGFIQCLA MIPGTSRSGA TIIGGMLSGL SRKAATEFSF FLAMPTMLGA
210 220 230 240 250
ATYDLLRNAD VLTSDNMLNI GLGFITAFIS ALFVVKALVR FVEKHTLRVF
260
AWYRIVLGII IMFVML
Length:266
Mass (Da):29,179
Last modified:July 19, 2004 - v1
Checksum:i34042859C40AF688
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR543861 Genomic DNA. Translation: CAG68488.1.
RefSeqiYP_046310.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG68488; CAG68488; ACIAD1642.
GeneIDi2878064.
KEGGiaci:ACIAD1642.
PATRICi20741052. VBIAciSp98416_1477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR543861 Genomic DNA. Translation: CAG68488.1 .
RefSeqi YP_046310.1. NC_005966.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62977.ACIAD1642.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG68488 ; CAG68488 ; ACIAD1642 .
GeneIDi 2878064.
KEGGi aci:ACIAD1642.
PATRICi 20741052. VBIAciSp98416_1477.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci ASP62977:GJVV-1553-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
    Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
    Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33305 / BD413 / ADP1.

Entry informationi

Entry nameiUPPP3_ACIAD
AccessioniPrimary (citable) accession number: Q6FBS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3