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Q6FBI2

- GCH4_ACIAD

UniProt

Q6FBI2 - GCH4_ACIAD

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, ACIAD1740
Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei151 – 1511May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciASP62977:GJVV-1650-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:ACIAD1740
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
ProteomesiUP000000430: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294GTP cyclohydrolase FolE2UniRule annotation
PRO_0000147697Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62977.ACIAD1740.

Structurei

3D structure databases

ProteinModelPortaliQ6FBI2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FBI2-1 [UniParc]FASTAAdd to Basket

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MNAQLPDVSV SQLPCNLSPL NWVGMQHIDL PTVIDTANQT VNTKVDVYVN    50
LPKSSVKGIH MSRLYHLINH LSVLNTMSIK SVLKQMIDSH QDCGTTAAKI 100
VFKFDLLLKR DAIVSTALSG WKSYPVIIEA SIINELFNIE YKLDISYSST 150
CPCSAALSRQ IIKNGFKADF SSQNLIPSAD IEAWLEQYAT LATPHSQRSI 200
ATVVVQPFDY AHDINFVDLI DSIENTLKTP TQTAVKRADE QAFAKLNGEN 250
LMFVEDAARR LKMLLDQKYK FWSAQVVHQE SLHPHDAIAV AISS 294
Length:294
Mass (Da):32,773
Last modified:July 19, 2004 - v1
Checksum:i2508F91EAD2D97B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR543861 Genomic DNA. Translation: CAG68580.1.
RefSeqiYP_046402.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG68580; CAG68580; ACIAD1740.
GeneIDi2878385.
KEGGiaci:ACIAD1740.
PATRICi20741246. VBIAciSp98416_1569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR543861 Genomic DNA. Translation: CAG68580.1 .
RefSeqi YP_046402.1. NC_005966.1.

3D structure databases

ProteinModelPortali Q6FBI2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 62977.ACIAD1740.

Protocols and materials databases

DNASUi 2878385.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG68580 ; CAG68580 ; ACIAD1740 .
GeneIDi 2878385.
KEGGi aci:ACIAD1740.
PATRICi 20741246. VBIAciSp98416_1569.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci ASP62977:GJVV-1650-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
    Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
    Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33305 / BD413 / ADP1.

Entry informationi

Entry nameiGCH4_ACIAD
AccessioniPrimary (citable) accession number: Q6FBI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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