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Q6FBI2

- GCH4_ACIAD

UniProt

Q6FBI2 - GCH4_ACIAD

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei151 – 1511May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciASP62977:GJVV-1650-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:ACIAD1740
    OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
    Taxonomic identifieri62977 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
    ProteomesiUP000000430: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294GTP cyclohydrolase FolE2PRO_0000147697Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi62977.ACIAD1740.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FBI2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiAGRTTIQ.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6FBI2-1 [UniParc]FASTAAdd to Basket

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    MNAQLPDVSV SQLPCNLSPL NWVGMQHIDL PTVIDTANQT VNTKVDVYVN    50
    LPKSSVKGIH MSRLYHLINH LSVLNTMSIK SVLKQMIDSH QDCGTTAAKI 100
    VFKFDLLLKR DAIVSTALSG WKSYPVIIEA SIINELFNIE YKLDISYSST 150
    CPCSAALSRQ IIKNGFKADF SSQNLIPSAD IEAWLEQYAT LATPHSQRSI 200
    ATVVVQPFDY AHDINFVDLI DSIENTLKTP TQTAVKRADE QAFAKLNGEN 250
    LMFVEDAARR LKMLLDQKYK FWSAQVVHQE SLHPHDAIAV AISS 294
    Length:294
    Mass (Da):32,773
    Last modified:July 19, 2004 - v1
    Checksum:i2508F91EAD2D97B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR543861 Genomic DNA. Translation: CAG68580.1.
    RefSeqiYP_046402.1. NC_005966.1.

    Genome annotation databases

    EnsemblBacteriaiCAG68580; CAG68580; ACIAD1740.
    GeneIDi2878385.
    KEGGiaci:ACIAD1740.
    PATRICi20741246. VBIAciSp98416_1569.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR543861 Genomic DNA. Translation: CAG68580.1 .
    RefSeqi YP_046402.1. NC_005966.1.

    3D structure databases

    ProteinModelPortali Q6FBI2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 62977.ACIAD1740.

    Protocols and materials databases

    DNASUi 2878385.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG68580 ; CAG68580 ; ACIAD1740 .
    GeneIDi 2878385.
    KEGGi aci:ACIAD1740.
    PATRICi 20741246. VBIAciSp98416_1569.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi AGRTTIQ.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci ASP62977:GJVV-1650-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
      Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
      Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33305 / BD413 / ADP1.

    Entry informationi

    Entry nameiGCH4_ACIAD
    AccessioniPrimary (citable) accession number: Q6FBI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3