Q6FBI2 (GCH4_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16

Gene names

Name:	folE2
Ordered Locus Names:	ACIAD1740

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	GTP cyclohydrolase folE2 HAMAP-Rule MF_01527		PRO_0000147697
Sites
	Site	151	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FBI2 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 2508F91EAD2D97B6	FASTA	294	32,773
	10 20 30 40 50 60 MNAQLPDVSV SQLPCNLSPL NWVGMQHIDL PTVIDTANQT VNTKVDVYVN LPKSSVKGIH 70 80 90 100 110 120 MSRLYHLINH LSVLNTMSIK SVLKQMIDSH QDCGTTAAKI VFKFDLLLKR DAIVSTALSG 130 140 150 160 170 180 WKSYPVIIEA SIINELFNIE YKLDISYSST CPCSAALSRQ IIKNGFKADF SSQNLIPSAD 190 200 210 220 230 240 IEAWLEQYAT LATPHSQRSI ATVVVQPFDY AHDINFVDLI DSIENTLKTP TQTAVKRADE 250 260 270 280 290 QAFAKLNGEN LMFVEDAARR LKMLLDQKYK FWSAQVVHQE SLHPHDAIAV AISS

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ADP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG68580.1.
RefSeq	YP_046402.1. NC_005966.1.
3D structure databases
ProteinModelPortal	Q6FBI2.
ModBase	Search...
Protein-protein interaction databases
STRING	62977.ACIAD1740.
Protocols and materials databases
DNASU	2878385.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAG68580; CAG68580; ACIAD1740.
GeneID	2878385.
KEGG	aci:ACIAD1740.
PATRIC	20741246. VBIAciSp98416_1569.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000247517.
KO	K09007.
OMA	LNGQNLM.
ProtClustDB	PRK13674.
Enzyme and pathway databases
BioCyc	ASP62977:GJVV-1650-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 2 hits.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH4_ACIAD

Accession

Primary (citable) accession number: Q6FBI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program