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Q6FBI2

- GCH4_ACIAD

UniProt

Q6FBI2 - GCH4_ACIAD

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei151 – 1511May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciASP62977:GJVV-1650-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:ACIAD1740
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
ProteomesiUP000000430: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294GTP cyclohydrolase FolE2PRO_0000147697Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62977.ACIAD1740.

Structurei

3D structure databases

ProteinModelPortaliQ6FBI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FBI2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAQLPDVSV SQLPCNLSPL NWVGMQHIDL PTVIDTANQT VNTKVDVYVN
60 70 80 90 100
LPKSSVKGIH MSRLYHLINH LSVLNTMSIK SVLKQMIDSH QDCGTTAAKI
110 120 130 140 150
VFKFDLLLKR DAIVSTALSG WKSYPVIIEA SIINELFNIE YKLDISYSST
160 170 180 190 200
CPCSAALSRQ IIKNGFKADF SSQNLIPSAD IEAWLEQYAT LATPHSQRSI
210 220 230 240 250
ATVVVQPFDY AHDINFVDLI DSIENTLKTP TQTAVKRADE QAFAKLNGEN
260 270 280 290
LMFVEDAARR LKMLLDQKYK FWSAQVVHQE SLHPHDAIAV AISS
Length:294
Mass (Da):32,773
Last modified:July 19, 2004 - v1
Checksum:i2508F91EAD2D97B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR543861 Genomic DNA. Translation: CAG68580.1.
RefSeqiYP_046402.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG68580; CAG68580; ACIAD1740.
GeneIDi2878385.
KEGGiaci:ACIAD1740.
PATRICi20741246. VBIAciSp98416_1569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR543861 Genomic DNA. Translation: CAG68580.1 .
RefSeqi YP_046402.1. NC_005966.1.

3D structure databases

ProteinModelPortali Q6FBI2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62977.ACIAD1740.

Protocols and materials databases

DNASUi 2878385.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG68580 ; CAG68580 ; ACIAD1740 .
GeneIDi 2878385.
KEGGi aci:ACIAD1740.
PATRICi 20741246. VBIAciSp98416_1569.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci ASP62977:GJVV-1650-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
    Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
    Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33305 / BD413 / ADP1.

Entry informationi

Entry nameiGCH4_ACIAD
AccessioniPrimary (citable) accession number: Q6FBI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 19, 2004
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3