Q6FB08 (PGK_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate kinase
EC=2.7.2.3

Gene names

Name:	pgk
Ordered Locus Names:	ACIAD1927

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP MF_00145
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP MF_00145
Subunit structure	Monomer By similarity. HAMAP MF_00145
Subcellular location	Cytoplasm Potential HAMAP MF_00145.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Phosphoglycerate kinase HAMAP MF_00145		PRO_1000057950
Regions
	Nucleotide binding	350 – 353	4	ATP By similarity
	Region	21 – 23	3	Substrate binding By similarity
	Region	59 – 62	4	Substrate binding By similarity
Sites
	Binding site	36	1	Substrate By similarity
	Binding site	113	1	Substrate By similarity
	Binding site	146	1	Substrate By similarity
	Binding site	197	1	ATP By similarity
	Binding site	324	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FB08 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 81E4DBD786DD0157	FASTA	395	41,256
	10 20 30 40 50 60 MNFKRMTDLD LSEKRVLIRE DLNVPVKNGQ ITSDARLRAA LPTIQAALAQ GAAVMVCSHL 70 80 90 100 110 120 GRPVEGEPKP EQSLAPVAAY LSDALGQEVK LLTDYLEGVE IAPGQVVLLE NVRFNLGEKK 130 140 150 160 170 180 NNAELAQKYA ALCDVFVMDA FGTAHRAEAS TEGAARYAKV AAAGPLLATE LDALGRALQT 190 200 210 220 230 240 PEKPMVAIVA GSKVSTKLDV LTSLSDICGQ LIVGGGIANT FLAAAGFNVG KSLCENDLID 250 260 270 280 290 300 TAKAIAAKVS VPLPTDVVVA DATEIDFADF LGSLAKAQAI VKKVEDIADN DMILDVGPDT 310 320 330 340 350 360 AKAFAEILKT AKTILWNGPV GVFEVDQFGE GTKTLSLAIA ESKGFSIAGG GDTLAAIDKY 370 380 390 KVADKIGYIS TGGGAFLEFV EGKTLPAVAV LLERA

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ADP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG68755.1.
RefSeq	YP_046577.1. NC_005966.1.
3D structure databases
HSSP	HSSP built from PDB template 1VPE based on UniProtKB P36204.
ProteinModelPortal	Q6FB08.
SMR	Q6FB08. Positions 5-395.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FB08.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2879593.
GenomeReviews	Gene locus ACIAD1927 in contig CR543861_GR.
KEGG	aci:ACIAD1927.
NMPDR	fig|62977.3.peg.1839.
PATRIC	20741584. VBIAciSp98416_1737.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0126.
HOGENOM	HBG453500.
OMA	AKPMAAI.
PhylomeDB	Q6FB08.
ProtClustDB	PRK00073.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD1927-MONOMER.
Family and domain databases
HAMAP	MF_00145. Phosphoglyc_kinase. [Tree]
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.1270. Phosphoglycerate_kinase_C. 1 hit. G3DSA:3.40.50.1260. Phosphoglycerate_kinase_N. 1 hit.
KO	K00927.
PANTHER	PTHR11406. PGK. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PIRSF	PIRSF000724. Pgk. 1 hit.
PRINTS	PR00477. PHGLYCKINASE.
SUPFAM	SSF53748. PGK. 1 hit.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK_ACIAD

Accession

Primary (citable) accession number: Q6FB08

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program