Reviewed, UniProtKB/Swiss-Prot Q6FAT8 (KDSA_ACIAD)

Names and origin

Protein names

Recommended name:
    2-dehydro-3-deoxyphosphooctonate aldolase
    EC=2.5.1.55
Alternative name(s):
    Phospho-2-dehydro-3-deoxyoctonate aldolase
    3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase
    KDO-8-phosphate synthetase
      Short name=KDO 8-P synthase
      Short name=KDOPS

Gene names

Name:	kdsA
Ordered Locus Names:	ACIAD2002

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056
Subcellular location	Cytoplasm By similarity HAMAP MF_00056.
Sequence similarities	Belongs to the kdsA family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	2-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056		PRO_0000187096

Sequences

	Sequence		Length	Mass (Da)
	Q6FAT8-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 3D3FA2A7CE2A1C46	FASTA	285	31,534
	10 20 30 40 50 60 MSQLKPQEIV RLGDIQMANH LPFVLFGGMN VLESKDLAFE IAETYVDICK RLEIPYVFKA 70 80 90 100 110 120 SFDKANRSSL HSFRGPGLEK GIEWLGEIKK HFNVPIITDV HEPYQAAPVA EVADIIQLPA 130 140 150 160 170 180 FLSRQTDLVE AMAKTQAIIN IKKAQFLSPR EMNHILNKCL EAGNDKLILC ERGTSFGYNN 190 200 210 220 230 240 LVVDMLGFDT MKEMNVPVFF DVTHALQTPG GRADSAGGRR AQITTLARAG MATGLAGLFL 250 260 270 280 EAHPDPEKAK CDGPCALRLS QLEPFLAQLK ELDALVKGFK KLDTH

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG68825.1.
RefSeq	YP_046647.1.
3D structure databases
SMR	Q6FAT8. Positions 7-284.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FAT8.
Genome annotation databases
GeneID	2879978.
GenomeReviews	Gene locus ACIAD2002 in contig CR543861_GR.
KEGG	aci:ACIAD2002.
NMPDR	fig|62977.3.peg.1909.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2877.
HOGENOM	HBG575990.
OMA	VHEPHQA.
PhylomeDB	Q6FAT8.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD2002-MONOMER.
Family and domain databases
HAMAP	MF_00056. KDO8P_synth. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21057:SF2. KDO8P_synthase. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01362. KDO8P_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSA_ACIAD

Accession

Primary (citable) accession number: Q6FAT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)