Reviewed, UniProtKB/Swiss-Prot Q6FA87 (PPNK_ACIAD)

Names and origin

Protein names

Recommended name:
    Probable inorganic polyphosphate/ATP-NAD kinase
      Short name=Poly(P)/ATP NAD kinase
    EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	ACIAD2231

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_0000229595

Sequences

	Sequence		Length	Mass (Da)
	Q6FA87-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: A973C9908B2F0C79	FASTA	307	33,823
	10 20 30 40 50 60 MQSANLSSAK SFRNIGLIGR PDKISVVETL CLIHDHLRGL GLHVIFDQET AELVPYTNVQ 70 80 90 100 110 120 TASRSLLGEV VDLVIVVGGD GSLLHAARAL VRHHTPVIGI NRGRLGFLTD IKPADALFKL 130 140 150 160 170 180 DQVLKGHFQL DRRFLLEMEV RTKGETLYDA IALNDVVLHS GKSVHMIDFE LQIDGQYVYR 190 200 210 220 230 240 QHSDGLIVST PTGSTAYALS GGGPILHPSM DAIALVPMHP HTLSSRPIVV GGQSEIKLTI 250 260 270 280 290 300 RENRVLPMVS ADGQHSVSLN VGDCVHIRKH PFKLNLLHPP GYDFYMACRT KLGWNQDFDL IKEQDDS

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG69026.1.
RefSeq	YP_046848.1.
3D structure databases
SMR	Q6FA87. Positions 11-298.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FA87.
Genome annotation databases
GeneID	2880239.
GenomeReviews	Gene locus ACIAD2231 in contig CR543861_GR.
KEGG	aci:ACIAD2231.
NMPDR	fig|62977.3.peg.2135.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
HOGENOM	HBG713904.
OMA	DPRLDVI.
PhylomeDB	Q6FA87.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD2231-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. ATP_NADK. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPNK_ACIAD

Accession

Primary (citable) accession number: Q6FA87

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	July 19, 2004
Last modified:	January 19, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)