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Q6FA87 (NADK_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:ACIAD2231
OrganismAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) [Complete proteome] [HAMAP]
Taxonomic identifier62977 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307NAD kinase HAMAP-Rule MF_00361
PRO_0000229595

Regions

Nucleotide binding80 – 812NAD By similarity
Nucleotide binding154 – 1552NAD By similarity
Nucleotide binding195 – 2006NAD By similarity

Sites

Active site801Proton acceptor By similarity
Binding site851NAD By similarity
Binding site1651NAD By similarity
Binding site1821NAD By similarity
Binding site1841NAD By similarity
Binding site2541NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FA87 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: A973C9908B2F0C79

FASTA30733,823
        10         20         30         40         50         60 
MQSANLSSAK SFRNIGLIGR PDKISVVETL CLIHDHLRGL GLHVIFDQET AELVPYTNVQ 

        70         80         90        100        110        120 
TASRSLLGEV VDLVIVVGGD GSLLHAARAL VRHHTPVIGI NRGRLGFLTD IKPADALFKL 

       130        140        150        160        170        180 
DQVLKGHFQL DRRFLLEMEV RTKGETLYDA IALNDVVLHS GKSVHMIDFE LQIDGQYVYR 

       190        200        210        220        230        240 
QHSDGLIVST PTGSTAYALS GGGPILHPSM DAIALVPMHP HTLSSRPIVV GGQSEIKLTI 

       250        260        270        280        290        300 
RENRVLPMVS ADGQHSVSLN VGDCVHIRKH PFKLNLLHPP GYDFYMACRT KLGWNQDFDL 


IKEQDDS 

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References

[1]"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33305 / BD413 / ADP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR543861 Genomic DNA. Translation: CAG69026.1.
RefSeqYP_046848.1. NC_005966.1.

3D structure databases

ProteinModelPortalQ6FA87.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING62977.ACIAD2231.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG69026; CAG69026; ACIAD2231.
GeneID2880239.
KEGGaci:ACIAD2231.
PATRIC20742122. VBIAciSp98416_2004.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227221.
KOK00858.
OMATHEMLYH.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycASP62977:GJVV-2099-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_ACIAD
AccessionPrimary (citable) accession number: Q6FA87
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families